cardiac arrhythmia;
ion channels;
mitochondria;
reactive oxygen species;
D O I:
10.1111/j.1440-1681.2006.04341.x
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
1. Reactive oxygen species (ROS) have been considered deleterious to cell function and there is good evidence to suggest that they play a role in the pathophysiology of a number of cardiac disease states. However, ROS are also now being recognized as important regulators of cell function by altering the redox state of proteins. 2. Possible sources of production of ROS in cardiac myocytes are the mitochondria and nicotinamide adenine dinucleotide phosphate-oxidase. The generation of ROS and anti-oxidant defence mechanisms in the heart are discussed. 3. The evidence for a role for ROS in the development of disease states, such as atherosclerosis, ischaemia, cardiac hypertrophy and hypertension, is presented. It is now recognized that cardiac ion channel function is regulated by ROS. Implications with respect to cardiac arrhythmia are discussed.
机构:
Univ Illinois, Cardiol Sect, Jesse Brown VA Med Ctr, Div Cardiol, Chicago, IL 60612 USAUniv Illinois, Cardiol Sect, Jesse Brown VA Med Ctr, Div Cardiol, Chicago, IL 60612 USA
Liu, Man
Liu, Hong
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机构:
Univ Illinois, Cardiol Sect, Jesse Brown VA Med Ctr, Div Cardiol, Chicago, IL 60612 USAUniv Illinois, Cardiol Sect, Jesse Brown VA Med Ctr, Div Cardiol, Chicago, IL 60612 USA
Liu, Hong
Dudley, Samuel C., Jr.
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机构:
Univ Illinois, Cardiol Sect, Jesse Brown VA Med Ctr, Div Cardiol, Chicago, IL 60612 USAUniv Illinois, Cardiol Sect, Jesse Brown VA Med Ctr, Div Cardiol, Chicago, IL 60612 USA
机构:
Univ Bari, Sch Med, Dept Pharmacol & Human Physiol, Bari, ItalyNew York Med Coll, Dept Med & Pharmacol, Renal Res Unit, Renal Res Inst, Valhalla, NY 10595 USA
Addabbo, Francesco
Montagnani, Monica
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机构:
Univ Bari, Sch Med, Dept Pharmacol & Human Physiol, Bari, ItalyNew York Med Coll, Dept Med & Pharmacol, Renal Res Unit, Renal Res Inst, Valhalla, NY 10595 USA
Montagnani, Monica
Goligorsky, Michael S.
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机构:
New York Med Coll, Dept Med & Pharmacol, Renal Res Unit, Renal Res Inst, Valhalla, NY 10595 USANew York Med Coll, Dept Med & Pharmacol, Renal Res Unit, Renal Res Inst, Valhalla, NY 10595 USA
机构:
Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, MexicoUniv Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, Mexico
Padilla-Flores, Teresa
Lopez-Gonzalez, Zinaeli
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机构:
Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, MexicoUniv Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, Mexico
Lopez-Gonzalez, Zinaeli
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机构:
Vaca, Luis
Emiliano Aparicio-Trejo, Omar
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h-index: 0
机构:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Mexico City 04510, DF, MexicoUniv Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, Mexico
Emiliano Aparicio-Trejo, Omar
Briones-Herrera, Alfredo
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h-index: 0
机构:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Mexico City 04510, DF, MexicoUniv Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, Mexico
Briones-Herrera, Alfredo
Riveros-Rosas, Hector
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机构:
Univ Nacl Autonoma Mexico, Fac Med, Dept Bioquim, Mexico City 04510, DF, MexicoUniv Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, Mexico
Riveros-Rosas, Hector
Pedraza-Chaverri, Jose
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机构:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Mexico City 04510, DF, MexicoUniv Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, Mexico
Pedraza-Chaverri, Jose
Leon-Aparicio, Daniel
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h-index: 0
机构:
Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, MexicoUniv Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, Mexico
Leon-Aparicio, Daniel
Salvador, Carolina
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机构:
Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, MexicoUniv Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, Mexico
Salvador, Carolina
Sampieri, Alicia
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机构:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Biol Celular & Desarrollo, Mexico City 04510, DF, MexicoUniv Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, Mexico
Sampieri, Alicia
Escobar, Laura, I
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Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, MexicoUniv Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, Mexico
机构:
Fdn Ctr Nacl Invest Cardiovasc Carlos III CNIC, Madrid 28029, SpainFdn Ctr Nacl Invest Cardiovasc Carlos III CNIC, Madrid 28029, Spain
Hernansanz-Agustin, Pablo
Enriquez, Jose Antonio
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机构:
Fdn Ctr Nacl Invest Cardiovasc Carlos III CNIC, Madrid 28029, Spain
Saludable CIBERFES, Ctr Invest Biomed Red Fragilidad & Envejecimiento, Av Monforte Lemos, Madrid 28029, SpainFdn Ctr Nacl Invest Cardiovasc Carlos III CNIC, Madrid 28029, Spain