CD99 expression and newly diagnosed diffuse large B-cell lymphoma treated with rituximab-CHOP immunochemotherapy

被引：19

作者：

Hong, Junshik ^{[1
]}

Park, Sanghui ^{[2
]}

Park, Jinny ^{[1
]}

Jang, Seung Jun ^{[1
]}

Ahn, Hee Kyung ^{[1
]}

Sym, Sun Jin ^{[1
]}

Cho, Eun Kyung ^{[1
]}

Shin, Dong Bok ^{[1
]}

Lee, Jae Hoon ^{[1
]}

机构：

[1] Gachon Univ, Dept Internal Med, Sch Med, Inchon 405760, South Korea

[2] Ewha Womans Univ, Dept Pathol, Sch Med, Seoul 158710, South Korea

来源：

ANNALS OF HEMATOLOGY | 2012年 / 91卷 / 12期

关键词：

CD99; Diffuse large B-cell lymphoma; Prognosis; Immunohistochemistry; TISSUE MICROARRAY; GERMINAL CENTER; PROGNOSTIC IMPACT; EWINGS-SARCOMA; R-CHOP; IMMUNOREACTIVITY; CLASSIFICATION; CHEMOTHERAPY; DOXORUBICIN; VALIDATION;

D O I：

10.1007/s00277-012-1533-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In order to evaluate prognostic value of CD99 expression in patients with diffuse large B-cell lymphoma (DLBCL) who underwent treatment with rituximab-CHOP immunochemotherapy, immunohistochemistry for CD99/CD10/BCL-2/BCL-6/MUM-1 was performed on nodal DLBCL specimens from 70 patients. Patients were classified as either germinal center B-cell (GCB) subtype or non-GCB subtype according to the Muris algorithm. A superior 2-year event-free survival (EFS) was observed in patients with the GCB subgroup, compared to those with the non-GCB subgroup (p = 0.034). The distribution of CD99 expression (29 patients; 41.4 %) did not show deviation according to subtype and was not prognostic for survival in the entire patient population. Among patients with the GCB subgroup, better EFS and overall survival (OS) were observed in CD99+ patients, compared to CD99- patients. Conversely, among patients with the non-GCB subgroup, inferior EFS and OS were reported in CD99+ patients. Superior 2-year EFS (p = 0.004) and 2-year OS (p = 0.003) were observed in patients with GCB/CD99+ and non-GCB/CD99- compared to the others, and the combination classification was found to be an independent prognostic factor.

引用

页码：1897 / 1906

页数：10

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