Functional Nucleic Acid Nanomaterials: Development, Properties, and Applications

被引:138
作者
Xu, Wentao [1 ,2 ]
He, Wanchong [1 ,2 ]
Du, Zaihui [1 ,2 ]
Zhu, Liye [1 ,2 ]
Huang, Kunlun [1 ,2 ]
Lu, Yi [3 ]
Luo, Yunbo [1 ,2 ]
机构
[1] China Agr Univ, Key Lab Precis Nutr & Food Qual, Dept Nutr & Hlth, Beijing 100083, Peoples R China
[2] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
[3] Univ Illinois, Dept Chem, Urbana, IL 61801 USA
关键词
aptamers; bioimaging; biosensing; DNAzymes; functional nucleic acids; MESOPOROUS SILICA NANOPARTICLES; METAL-ORGANIC FRAMEWORKS; IN-VITRO SELECTION; ROLLING CIRCLE AMPLIFICATION; SMALL-MOLECULE TARGETS; SINGLE-STRANDED-DNA; GOLD NANOPARTICLES; CATALYTIC DNA; ULTRASENSITIVE DETECTION; MAGNETOTACTIC BACTERIA;
D O I
10.1002/anie.201909927
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Functional nucleic acid (FNA) nanotechnology is an interdisciplinary field between nucleic acid biochemistry and nanotechnology that focuses on the study of interactions between FNAs and nanomaterials and explores the particular advantages and applications of FNA nanomaterials. With the goal of building the next-generation biomaterials that combine the advantages of FNAs and nanomaterials, the interactions between FNAs and nanomaterials as well as FNA self-assembly technologies have established themselves as hot research areas, where the target recognition, response, and self-assembly ability, combined with the plasmon properties, stability, stimuli-response, and delivery potential of various nanomaterials can give rise to a variety of novel fascinating applications. As research on the structural and functional group features of FNAs and nanomaterials rapidly develops, many laboratories have reported numerous methods to construct FNA nanomaterials. In this Review, we first introduce some widely used FNAs and nanomaterials along with their classification, structure, and application features. Then we discuss the most successful methods employing FNAs and nanomaterials as elements for creating advanced FNA nanomaterials. Finally, we review the extensive applications of FNA nanomaterials in bioimaging, biosensing, biomedicine, and other important fields, with their own advantages and drawbacks, and provide our perspective about the issues and developing trends in FNA nanotechnology.
引用
收藏
页码:6890 / 6918
页数:29
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