The PdCl2-catalyzed sequential heterocyclization/Michael addition cascade in the synthesis of 2,3-disubstituted indoles

被引：31

作者：

Janreddy, Donala ^{[1
]}

Kavala, Veerababurao ^{[1
]}

Kuo, Chun-Wei ^{[1
]}

Kuo, Ting-Shen ^{[1
]}

He, Chiu-Hui ^{[1
]}

Yao, Ching-Fa ^{[1
]}

机构：

[1] Natl Taiwan Normal Univ, Dept Chem, Taipei 116, Taiwan

来源：

TETRAHEDRON | 2013年 / 69卷 / 15期

关键词：

Cascade reaction; PdCl2; 2,3-Disubstituted indoles; 2-Alkynylanilines; alpha; beta-Unsaturated ketones; ONE-POT SYNTHESIS; CATALYZED SYNTHESIS; CYCLIZATION; DERIVATIVES; BENZOFURANS;

D O I：

10.1016/j.tet.2013.01.081

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cascade reaction of 2-N-unprotected-2-alkynylanilines and various electron-deficient alkenes in the presence of PdCl2 provided 2,3-disubstituted indole derivatives, whereas, in the presence of Pd(OAc)(2), the same reaction resulted in the production of N-alkylated-2-alkynylaniline derivatives. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：3323 / 3330

页数：8

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