Association between the variable number of tandem repeat polymorphism in the third exon of the dopamine D4 receptor gene and sensitivity to analgesics and pain in patients undergoing painful cosmetic surgery

被引:8
作者
Aoki, Yoshinori [1 ,2 ]
Nishizawa, Daisuke [1 ]
Kasai, Shinya [1 ]
Fukuda, Ken-ichi [2 ]
Ichinohe, Tatsuya [3 ]
Yamashita, Shuichiro [4 ]
Ikeda, Kazutaka [1 ]
机构
[1] Tokyo Metropolitan Inst Med Sci, Addict Subst Project, Setagaya Ku, Tokyo 1568506, Japan
[2] Tokyo Dent Coll, Orofacial Pain Ctr,Suidoubashi Hosp, Dept Oral Hlth & Clin Sci,Div Dent Anesthesiol, Chiyoda Ku, Tokyo 1010061, Japan
[3] Tokyo Dent Coll, Dept Dent Anesthesiol, Mihama Ku, Chiba 2618502, Japan
[4] Tokyo Dent Coll, Div Prosthodont, Dept Oral Hlth & Clin Sci, Chiyoda Ku, Tokyo 1010061, Japan
关键词
Dopamine D-4 receptor; Japanese; Opioid; PCA; Postoperative pain; VNTR; REQUIREMENTS; DRD4;
D O I
10.1016/j.neulet.2013.02.039
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
To elucidate the mechanisms of individual differences in pain and analgesic sensitivity, we analyzed the variable number of tandem repeat polymorphism in the third exon of the dopamine D-4 receptor gene. Alleles that were less than four repeats long and four or more repeats long were considered Short and Long, respectively. We found that the Short/Short genotype group was significantly more sensitive to pain and less sensitive to analgesics than the Short/Long + Long/Long genotype group. Our data suggest that this polymorphism may predict individual differences in pain and analgesic sensitivity and help achieve adequate pain control in the future. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:1 / 4
页数:4
相关论文
共 14 条
[1]   Genetic polymorphisms in folate pathway enzymes, DRD4 and GSTM1 are related to temporomandibular disorder [J].
Aneiros-Guerrero, Angel ;
Lendinez, Ana M. ;
Palomares, Arturo R. ;
Perez-Nevot, Beatriz ;
Aguado, Lidia ;
Mayor-Olea, Alvaro ;
Ruiz-Galdon, Maximiliano ;
Reyes-Engel, Armando .
BMC MEDICAL GENETICS, 2011, 12
[2]   MODULATION OF INTRACELLULAR CYCLIC-AMP LEVELS BY DIFFERENT HUMAN DOPAMINE D4 RECEPTOR VARIANTS [J].
ASGHARI, V ;
SANYAL, S ;
BUCHWALDT, S ;
PATERSON, A ;
JOVANOVIC, V ;
VANTOL, HHM .
JOURNAL OF NEUROCHEMISTRY, 1995, 65 (03) :1157-1165
[3]   A genetic association study of dopamine metabolism-related genes and chronic headache with drug abuse [J].
Cevoli, S. ;
Mochi, M. ;
Scapoli, C. ;
Marzocchi, N. ;
Pierangeli, G. ;
Pini, L. A. ;
Cortelli, P. ;
Montagna, P. .
EUROPEAN JOURNAL OF NEUROLOGY, 2006, 13 (09) :1009-1013
[4]   The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus [J].
Chang, FM ;
Kidd, JR ;
Livak, KJ ;
Pakstis, AJ ;
Kidd, KK .
HUMAN GENETICS, 1996, 98 (01) :91-101
[5]   An association between fibromyalgia and the dopamine D4 receptor exon III repeat polymorphism and relationship to novelty seeking personality traits [J].
Dan, B ;
Hagit, C ;
Lily, N ;
Ebstein, RP .
MOLECULAR PSYCHIATRY, 2004, 9 (08) :730-731
[6]   Association between OPRM1 gene polymorphisms and fentanyl sensitivity in patients undergoing painful cosmetic surgery [J].
Fukuda, Kenichi ;
Hayashida, Masakazu ;
Ide, Soichiro ;
Saita, Naoko ;
Kokita, Yoshihiko ;
Kasai, Shinya ;
Nishizawa, Daisuke ;
Ogai, Yasukazu ;
Hasegawa, Junko ;
Nagashima, Makoto ;
Tagami, Megumi ;
Komatsu, Hiroshi ;
Sora, Ichiro ;
Koga, Hisashi ;
Kaneko, Yuzuru ;
Ikeda, Kazutaka .
PAIN, 2009, 147 (1-3) :194-201
[7]   Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype [J].
Hayashida, Masakazu ;
Nagashima, Makoto ;
Satoh, Yasuo ;
Katoh, Ryoji ;
Tagami, Megumi ;
Ide, Soichiro ;
Kasai, Shinya ;
Nishizawa, Daisuke ;
Ogai, Yasukazu ;
Hasegawa, Junko ;
Komatsu, Hiroshi ;
Sora, Ichiro ;
Fukuda, Kenichi ;
Koga, Hisashi ;
Hanaoka, Kazuo ;
Ikeda, Kazutaka .
PHARMACOGENOMICS, 2008, 9 (11) :1605-1616
[8]   Involvement of G-protein-activated inwardly rectifying K+ (GIRK) channels in opioid-induced analgesia [J].
Ikeda, K ;
Kobayashi, T ;
Kumanishi, T ;
Niki, H ;
Yano, R .
NEUROSCIENCE RESEARCH, 2000, 38 (01) :113-116
[9]   Molecular mechanisms of analgesia induced by opioids and ethanol: is the GIRK channel one of the keys? [J].
Ikeda, K ;
Kobayashi, T ;
Kumanishi, T ;
Yano, R ;
Sora, I ;
Niki, H .
NEUROSCIENCE RESEARCH, 2002, 44 (02) :121-131
[10]   Effect of postoperative analgesia on surgical outcome [J].
Kehlet, H ;
Holte, K .
BRITISH JOURNAL OF ANAESTHESIA, 2001, 87 (01) :62-72