End Points for Clinical Trials in Acute Kidney Injury

被引：19

作者：

Leaf, David E. ^{[1
]}

Waikar, Sushrut S. ^{[1
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Div Renal Med, Boston, MA USA

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 2017年 / 69卷 / 01期

关键词：

Acute kidney injury (AKI); acute renal failure (ARF); AKDI definition; end point; outcome; clinical trial; biomarker; randomized controlled trial; study design; ACUTE-RENAL-FAILURE; AKI; MORTALITY; OUTCOMES; NEPHROPATHY; INTERVENTION; ROSUVASTATIN; DEFINITIONS; ASSOCIATION; PREVENTION;

D O I：

10.1053/j.ajkd.2016.05.033

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Acute kidney injury (AKI) is an increasingly common and feared complication in hospitalized patients. The selection of appropriate primary and secondary end points is critical to the design and eventual success of clinical trials aimed at preventing and treating AKI. In this article, we provide an overview of AKI definitions and suggestions on the rational selection of end points for clinical trials in various settings, including the prevention of contrast-induced AKI, prevention of cardiac surgery-associated AKI, treatment of established AKI, and treatment of dialysis-requiring AKI. (C) 2016 by the National Kidney Foundation, Inc.

引用

页码：108 / 116

页数：9

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