Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism

被引：43

作者：

Kain, Vasundhara ^{[1
]}

Kapadia, Bandish ^{[1
]}

Misra, Parimal ^{[1
]}

Saxena, Uday ^{[2
]}

机构：

[1] Univ Hyderabad Campus, Dept Biol, Dr Reddys Inst Life Sci, Hyderabad, Telangana, India

[2] Kareus Therapeut SA, La Chaux De Fonds, Switzerland

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

关键词：

CORONARY-HEART-DISEASE; MYOCARDIAL-INFARCTION; LOWERING THERAPY; COENZYME-A; STATINS; PRAVASTATIN; METABOLISM; MEVINOLIN; SURVIVAL; GLUCOSE;

D O I：

10.1038/srep13823

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Statins are a class of oral drugs that are widely used for treatment of hypercholesterolemia. Recent clinical data suggest that chronic use of these drugs increases the frequency of new onset diabetes. Studies to define the risks of statin-induced diabetes and its underlying mechanisms are clearly necessary. We explored the possible mechanism of statin induced insulin resistance using a well-established cell based model and simvastatin as a prototype statin. Our data show that simvastatin induces insulin resistance in a cholesterol biosynthesis inhibition independent fashion but does so by a fatty acid mediated effect on insulin signaling pathway. These data may help design strategies for prevention of statin induced insulin resistance and diabetes in patients with hypercholesterolemia.

引用

页数：9

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