Noninferiority of 99mTc-Ethylenedicysteine-Glucosamine as an Alternative Analogue to 18F-Fluorodeoxyglucose in the Detection and Staging of Non-Small Cell Lung Cancer

被引:13
作者
Dai, Dong [1 ]
Rollo, F. David [2 ]
Bryant, Jerry [2 ]
Kim, E. Edmund [3 ,4 ]
机构
[1] Tianjin Med Univ Canc Inst & Hosp, Tianjin, Peoples R China
[2] Cell Point Biotechnol, Centennial, CO USA
[3] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
[4] Univ Calif Irvine, Irvine, CA USA
基金
中国国家自然科学基金;
关键词
HEXOSAMINE BIOSYNTHETIC-PATHWAY; N-ACETYLGLUCOSAMINE TRANSPORTER; GROWTH-FACTOR; O-GLCNAC; GLUCOSE; GLYCOSYLATION; TRANSCRIPTION; PROTEINS; NUCLEAR; SYSTEM;
D O I
10.1155/2018/8969714
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objective. Tc-99m-ethylenedicysteine-glucosamine (Tc-99m-EC-G) was developed as a potential alternative to F-18-FDG for cancer imaging. A Phase 2 study was conducted to compare F-18-FDG PET/CT and Tc-99m-EC-G SPECT/CT in the detection and staging of patients with non-small cell lung cancer (NSCLC). This study was aimed to demonstrate that Tc-99m-EC-G SPECT/CT was not inferior to F-18-FDG PET/CT in patients with confirmed NSCLC. Methods. Seventeen patients with biopsy proven NSCLC were imaged with Tc-99m-EC-G and F-18-FDG to detect and stage their cancers. Imaging with PET/CT began 45-60 minutes after injection of F-18-FDG. Imaging with Tc-99m-EC-G began at two hours after injection (for 5 patients) or three hours (for 12 patients). SPECT/CT imaging devices from the three major vendors of SPECT/CT systems were used at 6 participating study sites. The image sets were blinded to all clinical information and interpreted by independent PET and SPECT expert readers at a central independent core laboratory. Results. 100% concordance between Tc-99m-EC-G and F-18-FDG for primary lesion detection, lesion location and size, and confidence that the biopsied lesion was malignant. There was 70% agreement between Tc-99m-EC-G and F-18-FDG for metastatic lesion detection, location and size, and confidence that the suspicious lesions were malignant. Conclusions. Evaluation of primary and suspicious metastatic lesions detected by Tc-99m-EC-G and F-18-FDG on 17 patients resulted in excellent agreement for detection of primary and metastatic lesions. The study results indicated that Tc-99m-EC-G SPECT/CT has the potential to be a clinically viable alternative to F-18-FDG PET/CT and Tc-99m-EC-G is not inferior to F-18-FDG PET/CT.
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页数:9
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