Reflux finding score and reflux symptom index as potential predictors for proton pump inhibitor response in globus pharyngeus patients: A prospective study

被引:6
作者
Boom, Laurentine [1 ,3 ]
Edens, Mireille [2 ]
Rinia, Bas [1 ]
机构
[1] Isala Clin, Dept Otorhinolaryngol, Zwolle, Netherlands
[2] Isala Clin, Dept Innovat & Sci, Zwolle, Netherlands
[3] Admiralengracht 303 2, NL-1056 EB Amsterdam, Netherlands
关键词
Proton pump inhibitors; Reflux finding score; Reflux symptom index; Globus pharyngeus; Lower pharyngeal reflux; LARYNGOPHARYNGEAL REFLUX; METAANALYSIS; THERAPY; RELIABILITY; DIAGNOSIS; SENSATION; VALIDITY; RISK;
D O I
10.1016/j.anl.2020.02.002
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Objective: To evaluate the patient-reported reflux symptom index (RSI) and the doctors-reported Reflux finding score (RFS) as potential predictors for proton pump inhibitor (PPI) response in patients with suspected lower pharyngeal reflux, presenting with globus pharyngeus as their primary complaint. Methods: The research project was performed at the ENT department of Isala hospital Zwolle, the Netherlands. A before and after design was used for this single institution prospective exploratory study. 101 participants with globus pharyngeus symptoms as a primary complaint were included. All participants were assessed by an otorhinolaryngologist at enrollment and after eight weeks of esomeprazole use. Fiberoptic laryngoscopy was performed to document the RFS, and RSI questionnaires were self-administered by the participants. Our main outcome measurement was the patientreported therapeutic response evaluation, that differentiated three categories: responders, partial responders and non-responders. For evaluation of the assessment tools, RFS > 7 and RSI > 13 were considered deviant. Results: Among the 101 participants, 43 (42.6%) were responders, 28 (27.7%) partial responders and 30 (29.7%) non-responders. Both baseline RSI > 13 and RFS > 7 were statistically significant associated with treatment response. Also, combined into RSI/RFS baseline categories, a significant overall association between baseline scores and patient-reported treatment response was found. Patients reported success rates for deviant RSI and RFS baseline scores were 76.6% and 96%, respectively. 95.5% of patients with both deviant RSI and RFS baseline scores, reported (partial) treatment response. Conclusion: Both together, as well individually, pre-treatment RSI and RFS ratings can help predict treatment response of empirical PPI treatment in patients experiencing globus pharyngeus symptoms. (C) 2020 Oto-Rhino-Laryngological Society of Japan Inc. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:609 / 615
页数:7
相关论文
共 29 条
[1]  
Antoniou Tony, 2015, CMAJ Open, V3, pE166, DOI 10.9778/cmajo.20140074
[2]   Esophageal Disorders [J].
Aziz, Qasim ;
Fass, Ronnie ;
Gyawali, C. Prakash ;
Miwa, Hiroto ;
Pandolfino, John E. ;
Zerbib, Frank .
GASTROENTEROLOGY, 2016, 150 (06) :1368-1379
[3]   Treatment of chronic throat symptoms with PPIs should be preceded by pH monitoring - Pro: Empiric treatment with PPIs is not appropriate without testing [J].
Belafsky, PC .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2006, 101 (01) :6-8
[4]   The validity and reliability of the reflux finding score (RFS) [J].
Belafsky, PC ;
Postma, GN ;
Koufman, JA .
LARYNGOSCOPE, 2001, 111 (08) :1313-1317
[5]   Validity and reliability of the reflux symptom index (RSI) [J].
Belafsky, PC ;
Postma, GN ;
Koufman, JA .
JOURNAL OF VOICE, 2002, 16 (02) :274-277
[6]  
Campbell M., 2011, STAT SQUARE ONE, P123
[7]   Proton pump inhibitors linked to hypomagnesemia: a systematic review and meta-analysis of observational studies [J].
Cheungpasitporn, Wisit ;
Thongprayoon, Charat ;
Kittanamongkolchai, Wonngarm ;
Srivali, Narat ;
Edmonds, Peter J. ;
Ungprasert, Patompong ;
O'Corragain, Oisin A. ;
Korpaisarn, Sira ;
Erickson, Stephen B. .
RENAL FAILURE, 2015, 37 (07) :1237-1241
[8]   Meta-analysis: the effects of placebo treatment on gastro-oesophageal reflux disease [J].
Cremonini, F. ;
Ziogas, D. C. ;
Chang, H. Y. ;
Kokkotou, E. ;
Kelley, J. M. ;
Conboy, L. ;
Kaptchuk, T. J. ;
Lembo, A. J. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2010, 32 (01) :29-42
[9]   High-resolution manometry in patients with and without globus pharyngeus and/or symptoms of laryngopharyngeal reflux [J].
Ding, Heyan ;
Duan, Zhijun ;
Yang, Dong ;
Zhang, Zhifeng ;
Wang, Lixia ;
Sun, Xiaoyu ;
Yao, Yiwen ;
Lin, Xue ;
Yang, Hang ;
Wang, Shan ;
Chen, Jiande D. Z. .
BMC GASTROENTEROLOGY, 2017, 17
[10]   Use of acid-suppressive drugs and risk of pneumonia: a systematic review and meta-analysis [J].
Eom, Chun-Sick ;
Jeon, Christie Y. ;
Lim, Ju-Won ;
Cho, Eun-Geol ;
Park, Sang Min ;
Lee, Kang-Sook .
CANADIAN MEDICAL ASSOCIATION JOURNAL, 2011, 183 (03) :310-319