Plasma homocysteine levels are independently associated with the severity of peripheral polyneuropathy in type 2 diabetic subjects

被引:44
作者
Gonzalez, Ricardo [1 ,2 ]
Pedro, Teresa [1 ]
Martinez-Hervas, Sergio [1 ,3 ,4 ]
Civera, Miguel [1 ]
Antonia Priego, Maria [1 ]
Catala, Miguel [1 ,3 ]
Javier Chaves, F. [3 ,4 ]
Ascaso, Juan F. [1 ,3 ,4 ,5 ]
Carmena, Rafael [3 ,4 ,5 ]
Real, Jose T. [1 ,3 ,4 ,5 ]
机构
[1] Hosp Clin Univ Valencia, Serv Endocrinol & Nutr, Valencia 46010, Spain
[2] Ctr Salud Puerto Sagunto, Valencia, Spain
[3] CIBER Diabet & Enfermedades Metabol Asociada CIBE, Barcelona, Spain
[4] Hosp Clin Univ Valencia, Lab Estudios Gene, Fdn Invest, Inst Invest, Valencia 46010, Spain
[5] Univ Valencia, Dept Med, Valencia, Spain
关键词
microalbuminuria; NDS; peripheral polyneuropathy; plasma homocysteine; type 2 diabetes mellitus; CARDIOVASCULAR RISK-FACTORS; ARTERIAL-DISEASE; NEUROPATHY; COMPLICATIONS; POPULATION; MELLITUS;
D O I
10.1111/j.1529-8027.2012.00408.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Peripheral polyneuropathy (PN) is a frequent complication of diabetes. However, mechanisms underlying the development of PN are multifactorial and not well understood. Our aim was to examine the association of plasma homocysteine (Hcy) with the prevalence and grade of peripheral PN in patients with type 2 diabetes (T2DM). We studied a cohort of 196 subjects with T2DM classified according to the grade of PN (Neuropathy Disability Score, NDS). Subjects with the highest grade of PN were older and had significantly increased levels of creatinine, microalbuminuria, HbA1c, and plasma Hcy compared to the other two groups. The differences in plasma Hcy values were maintained after correcting for confounding factors. Plasma Hcy, HbA1c, duration of diabetes, and age were predictors of the grade of PN. In conclusion, for each increase of 1 mu mol in plasma Hcy there was a 23% increase of the risk of diabetic PN evaluated by NDS. Moreover, the grade of PN was predicted by plasma Hcy and HbA1c values, age and duration of diabetes. Further prospective studies should be conducted to confirm the association of plasma Hcy levels with the grade of PN in subjects with T2DM.
引用
收藏
页码:191 / 196
页数:6
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