What have we learned from SHIVA?

被引：22

作者：

Le Tourneau, Christophe ^{[1
,2
,3
]}

Kurzrock, Razelle ^{[4
,5
]}

机构：

[1] Inst Curie, Dept Med Oncol, 26 Rue Ulm, F-75005 Paris, France

[2] 35 Rue Dailly, F-92210 St Cloud, France

[3] Versailles St Quentin en Yvelines Univ, Unit EA7285, 2 Ave Source Bievre, F-78180 Montigny Le Bretonneux, France

[4] UCSD Moores Canc Ctr, Ctr Personalized Canc Therapy, 3855 Hlth Sci Dr 987, La Jolla, CA 92093 USA

[5] UCSD Moores Canc Ctr, Div Haematol & Oncol, 3855 Hlth Sci Dr 987, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS CLINICAL ONCOLOGY | 2016年 / 13卷 / 12期

关键词：

CONVENTIONAL THERAPY;

D O I：

10.1038/nrclinonc.2016.164

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The SHIVA trial compared the efficacy of targeted agents selected on the basis of tumour molecular profiling (using an algorithmic approach) with that of physician's choice across multiple solid tumours; the trial was negative for the primary end point. We now discuss the challenges associated with precision medicine trial design and propose solutions learned from this trial.

引用

页码：719 / 720

页数：2

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