Highly conformalreirradiation in patients with prior oropharyngeal radiation: Clinical efficacy and toxicity outcomes

被引：15

作者：

Bagley, Alexander F. ^{[1
]}

Garden, Adam S. ^{[1
]}

Reddy, Jay P. ^{[1
]}

Moreno, Amy C. ^{[1
]}

Frank, Steven J. ^{[1
]}

Rosenthal, David I. ^{[1
]}

Morrison, William H. ^{[1
]}

Gunn, Gary Brandon ^{[1
]}

Fuller, Clifton D. ^{[1
]}

Shah, Shalin J. ^{[1
]}

Ferrarotto, Renata ^{[2
]}

Sturgis, Erich M. ^{[3
]}

Gross, Neil D. ^{[3
]}

Phan, Jack ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, 1515 Holcombe Blvd,Unit 0097, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Houston, TX 77030 USA

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2020年 / 42卷 / 11期

关键词：

highly conformal radiotherapy; oropharyngeal carcinoma; reirradiation; SQUAMOUS-CELL CARCINOMA; CANCER-DISEASE-CONTROL; NECK-CANCER; RECURRENT HEAD; STEREOTACTIC RADIOTHERAPY; QUALITY-ASSURANCE; LOCALLY RECURRENT; THERAPY OUTCOMES; REIRRADIATION;

D O I：

10.1002/hed.26384

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background Reirradiation of head and neck cancer is associated with high rates of locoregional failure and potentially severe treatment-related toxicity. We report our institutional experience of reirradiation using modern highly conformal radiotherapy approaches in patients with prior oropharyngeal radiation. Methods We reviewed patients receiving curative-intent reirradiation with intensity-modulated radiation therapy, stereotactic body radiation therapy, and proton beam radiotherapy at our institution from 1999 to 2019. Disease control, survival, and toxicity rates following reirradiation were determined. Results Sixty-nine patients were evaluated. Local control (LC), progression-free survival, and overall survival at 2 years following reirradiation were 77%, 35%, and 51%, respectively. Grade 3 or greater (G3+) late toxicities occurred in 46% of patients and 41% required feeding tube placement during or after reirradiation. Conclusions In select patients with prior oropharyngeal radiation, highly conformal reirradiation offers acceptable LC, but G3+ toxicity and out-of-field failure rates remain high. These findings warrant continued evaluation of new multimodality approaches to improve oncologic outcomes.

引用

页码：3326 / 3335

页数：10

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