Sm(III)nitrate-catalyzed one-pot synthesis of furano[3,2c]-1,2,3,4-tetrahydroquinolines and DNA photocleavage studies

被引：14

作者：

Bindu, P. J. ^{[1
]}

Mahadevan, K. M. ^{[1
]}

Naik, T. R. Ravikumar ^{[2
]}

机构：

[1] Kuvempu Univ, Dept Studies & Res Chem, Shankaraghatta 577451, India

[2] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2012年 / 1020卷

关键词：

Sm(III)nitrate; Furano[3,2-c]-1,2,3,4-tetrahydroquinolines; DNA; Photocleavage; EFFICIENT SYNTHESIS; CONVENIENT SYNTHESIS; ALPHA-HALOKETONES; FACILE SYNTHESIS; AROMATIC-AMINES; DOMINO REACTION; DISCORHABDIN-C; WATER; 3,4-DIHYDRO-2H-PYRAN; ANTAGONISTS;

D O I：

10.1016/j.molstruc.2012.03.064

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The synthesis and DNA photocleavage studies of furano[3,2-c]-1,2,3,4-tetrahydroquinolines have been reported. Sm(III)nitrate was found to be an efficient for the Diels-Alder reaction of aryl amines with 2,3-dihydrofuran to offer the corresponding furano[3,2-c]-1,2,3,4-tetrahydroquinolines derivatives as a mixture of cis/trans stereoisomers in moderate yields. The aqueous solubility of acid catalyst can be recycled without significant loss of activity. The DNA photocleavage studies shows that, the cis/trans stereoisomers are good DNA cleavage mimic in terms of molecular structure. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：142 / 147

页数：6

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