Lipid apheresis applications in childhood: Experience in the University Hospital of Gazi

被引：4

作者：

Eminoglu, Tuba F. ^{[2
]}

Yenicesu, Idil ^{[1
]}

Tumer, Leyla ^{[3
]}

Okur, Ilyas ^{[2
]}

Dilsiz, Guenter ^{[3
]}

Hasanoglu, Alev ^{[2
]}

机构：

[1] Gazi Univ Hosp, Dept Pediat Hematol & Blood Bank, TR-06500 Ankara, Turkey

[2] Gazi Univ, Dept Pediat Metab & Nutr, Ankara, Turkey

[3] Gazi Univ, Blood Bank, Ankara, Turkey

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2008年 / 39卷 / 03期

关键词：

D O I：

10.1016/j.transci.2008.09.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The most commonly encountered complications in familial hypercholesterolemia (FH) are mainly cardiovascular in origin and the majority of cases unfortunately die due to this problem. LDL-apheresis is a proven therapeutic method in lowering this mortal risk. In this study we aimed to demonstrate the efficiency of LDL-apheresis performed by DALI or Cascade filtration on four pediatric patients with the diagnosis of homozygous FH. Applied LDL-apheresis techniques, side effects, laboratory results and cardiovascular follow-tip are discussed in the light of current literature. Our study has shown once again that lipid apheresis treatment in children with homozygous FH is the most effective treatment. The number of childhood subjects in whom lipid apheresis is performed is quite insufficient. There are no studies that compare DALI with cascade filtration in childhood subjects in our knowledge. The view of this aspect, this study will contribute to literature. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：235 / 240

页数：6

共 26 条

[1]

Agishi T, 1980, PLASMA EXCHANGE, P53

[2] Direct adsorption of lipoproteins from whole blood by direct adsorption of lipoprotein apheresis: First experience in two hypercholesterolemic children [J].

Bayrakci, US ;

Besbas, N ;

Ozcebe, O ;

Coskun, O ;

Akgul, E ;

Kutluk, T ;

Bakkaloglu, A .

THERAPEUTIC APHERESIS AND DIALYSIS, 2005, 9 (06) :469-472

[3] Atorvastatin dose-dependently decreases hepatic lipase activity in type 2 diabetes -: Effect of sex and the LIPC promoter variant [J].

Berk-Planken, IIL ;

Hoogerbrugge, N ;

Stolk, RP ;

Bootsma, AH ;

Jansen, H .

DIABETES CARE, 2003, 26 (02) :427-432

[4] Direct adsorption of low-density lipoprotein by DALI-LDL-apheresis: Results of a prospective long-term multicenter follow-up covering 12 291 sessions [J].

Bosch, T ;

Gahr, S ;

Belschner, U ;

Schaefer, C ;

Lennertz, A ;

Rammo, J .

THERAPEUTIC APHERESIS AND DIALYSIS, 2006, 10 (03) :210-218

[5]

Bosch T, 1997, ARTIF ORGANS, V21, P977

[6] Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease - Meta-analyses of prospective studies [J].

Danesh, J ;

Collins, R ;

Appleby, P ;

Peto, R .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 279 (18) :1477-1482

[7]

Geiss H C, 1999, Ther Apher, V3, P199, DOI 10.1046/j.1526-0968.1999.00157.x

[8]

GODEHARDT E, 1993, TREATMENT OF SEVERE DYSLIPOPROTEINEMIA IN THE PREVENTION OF CORONARY HEART DISEASE 4, P208

[9] LDL RECEPTOR LOCUS AND THE GENETICS OF FAMILIAL HYPERCHOLESTEROLEMIA [J].

GOLDSTEIN, JL ;

BROWN, MS .

ANNUAL REVIEW OF GENETICS, 1979, 13 :259-289

[10] Action of atorvastatin in combined hyperlipidemia - Preferential reduction of cholesteryl ester transfer from HDL to VLDL1 particles [J].

Guerin, M ;

Lassel, TS ;

Le Goff, W ;

Farnier, M ;

Chapman, MJ .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (01) :189-197

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