Viral etiology of prostate cancer: Genetic alterations and immune response. A literature review

被引：22
作者：
Abidi, Syed Hani [1 ]
Bilwani, Fareena [1 ]
Ghias, Kulsoom [1 ]
Abbas, Farhat [2 ]
机构：
[1] Aga Khan Univ, Dept Biol & Biomed Sci, Stadium Rd, Karachi, Pakistan
[2] Aga Khan Univ, Dept Surg, Stadium Rd, Karachi, Pakistan
来源：
INTERNATIONAL JOURNAL OF SURGERY | 2018年 / 52卷
关键词：
Prostate cancer; Virus; Immune system; Genetic; VIRUS-RELATED-VIRUS; SEXUALLY-TRANSMITTED INFECTIONS; EPSTEIN-BARR-VIRUS; HUMAN-PAPILLOMAVIRUS; RISK; INFLAMMATION; HPV; POLYMORPHISM; PREVALENCE; REVEALS;
D O I：
10.1016/j.ijsu.2018.02.050
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Prostate cancer is one of the most common cancers in men. Recent estimates suggest that over a million men are diagnosed with the disease annually. Prostate cancer pathogenesis involves both heritable and environmental factors. The molecular events involved in the development or progression of prostate cancer are still unclear. Recent body of literature highlights the role of viral infections in initiation or progression of prostate cancer. In this regard, certain viruses have been reported to interact with host proteins and bring about changes in genetic, immunological and inflammatory events that lead to initiation or progression of prostate cancer. We conducted a comprehensive PubMed database search to identify publications relevant to viruses associated with prostate cancer. In this review, we discuss the possible viral etiology of prostate cancer and evidence of viral-mediated genetic changes, and immune dysregulation involved in initiation or progression of prostate cancer.
引用
收藏
页码：136 / 140
页数：5
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