DNA binding, nuclease, and colon cancer cell inhibitory activity of a Cu(II) complex of a thiazolidine-4-carboxylic acid derivative

被引：28

作者：

Thalamuthu, S. ^{[1
]}

Annaraj, B. ^{[1
]}

Vasudevan, Smreti ^{[2
]}

Sengupta, Suparna ^{[2
]}

Neelakantan, M. A. ^{[1
]}

机构：

[1] Natl Engn Coll, Chem Res Ctr, Kovilpatti, India

[2] Rajiv Gandhi Ctr Biotechnol, Canc Res Program 3, Trivandrum, Kerala, India

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2013年 / 66卷 / 10期

关键词：

Thiazolidine-4-carboxylic acid derivative; Copper complex; Spectral studies; Biological activity; COPPER(II) COMPLEXES; MASS-SPECTROMETRY; CLEAVAGE ACTIVITY; METAL-COMPLEXES; LIGAND; RECOGNITION; BEHAVIOR; SPECTRA;

D O I：

10.1080/00958972.2013.791393

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Thiazolidine-4-carboxylic acid derivative (L) derived by condensation of D-penicillamine and 3-methoxy salicylaldehyde was used in synthesis of a copper complex (CuL). The ligand and Cu(II) complex were characterized by elemental analysis and spectral techniques. The DNA binding properties of L and CuL with calf thymus DNA were investigated by various techniques. The ability of compounds to break pUC19 DNA was checked by gel electrophoresis. The radical-scavenging activity was studied using 2,2-diphenyl-1-picrylhydrazyl assay. The ligand and CuL exert cytotoxicity against HCT116 cell line. The compounds were screened for antimicrobial activity against several microorganisms. The effect of the CuL on the surface of penicillium was analyzed by scanning electron microscopy.

引用

页码：1805 / 1820

页数：16

共 45 条

[1] Infinite zig-zag and cyclic-tetranuclear isomeric imidazolate-bridged polynuclear copper(II) complexes: Magnetic properties, catalytic activity and electrospray mass and tandem mass spectrometry characterization [J].