Studies have found naltrexone useful in the treatment of diseases other than opiate addiction in which endogenous opioids presumably play a role, such as alcoholism and eating disorders. Some of these studies involve high doses (100-200 mg bid). Because investigational studies with high doses (300 mg/day) reported clinically significant increases in liver enzyme levels, the authors measured a spectrum of liver function parameters in response to high doses of naltrexone in a double-blind, crossover trial (100 mg bid) followed by an open-label period (200 mg bid). They observed no adverse clinical or laboratory changes in liver function in association with high-dose naltrexone therapy in eating disorders.
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Univ Tokyo, Grad Sch Med, Dept Hematol & Oncol, Tokyo, JapanUniv Tokyo, Grad Sch Med, Dept Hematol & Oncol, Tokyo, Japan
Yamazaki, Sho
Nakamura, Fumihiko
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Univ Tokyo, Grad Sch Med, Dept Hematol & Oncol, Tokyo, JapanUniv Tokyo, Grad Sch Med, Dept Hematol & Oncol, Tokyo, Japan
Nakamura, Fumihiko
Yoshimi, Akihide
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Univ Tokyo, Grad Sch Med, Dept Hematol & Oncol, Tokyo, Japan
Tokyo Univ Hosp, Dept Cell Therapy & Transplantat Med, Tokyo 113, JapanUniv Tokyo, Grad Sch Med, Dept Hematol & Oncol, Tokyo, Japan
Yoshimi, Akihide
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Ichikawa, Motoshi
Nannya, Yasuhito
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Univ Tokyo, Grad Sch Med, Dept Hematol & Oncol, Tokyo, JapanUniv Tokyo, Grad Sch Med, Dept Hematol & Oncol, Tokyo, Japan
Nannya, Yasuhito
Kurokawa, Mineo
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Univ Tokyo, Grad Sch Med, Dept Hematol & Oncol, Tokyo, Japan
Tokyo Univ Hosp, Dept Cell Therapy & Transplantat Med, Tokyo 113, JapanUniv Tokyo, Grad Sch Med, Dept Hematol & Oncol, Tokyo, Japan
机构:
St Joseph Mercy Hosp, Dept Pharm, Ann Arbor, MI 48104 USASt Joseph Mercy Hosp, Dept Pharm, Ann Arbor, MI 48104 USA
Hecht, Jason P.
Mahmood, Syeda M.
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St Joseph Mercy Hosp, Dept Pharm, Ann Arbor, MI 48104 USA
Beaumont Hosp, Dept Pharm, Dearborn, MI USASt Joseph Mercy Hosp, Dept Pharm, Ann Arbor, MI 48104 USA
Mahmood, Syeda M.
Brandt, Mary-Margaret
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St Joseph Mercy Hosp, Dept Surg, Ann Arbor, MI 48104 USASt Joseph Mercy Hosp, Dept Pharm, Ann Arbor, MI 48104 USA
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Hosp Clin Univ Valladolid, Ctr Nacl Gripe Valladolid, Av Ramon y Cajal 3, Valladolid 47003, SpainHosp Clin Univ Valladolid, Ctr Nacl Gripe Valladolid, Av Ramon y Cajal 3, Valladolid 47003, Spain
Ortiz de Lejarazu, Raul
Martinon Torres, Federico
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Hosp Clin Univ Santiago, Serv Pediat, Santiago De Compostela, Spain
Inst Invest Sanitaria Santiago, Grp Genet Infecc & Vacunas Pediat GENVIP, Santiago De Compostela, SpainHosp Clin Univ Valladolid, Ctr Nacl Gripe Valladolid, Av Ramon y Cajal 3, Valladolid 47003, Spain
Martinon Torres, Federico
Gil de Miguel, Angel
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Univ Rey Juan Carlos, Dept Med Prevent & Salud Publ, Madrid, SpainHosp Clin Univ Valladolid, Ctr Nacl Gripe Valladolid, Av Ramon y Cajal 3, Valladolid 47003, Spain
Gil de Miguel, Angel
Diez Domingo, Javier
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Fdn Fomento Invest Sanitaria & Biomed Comunitat V, Valencia, SpainHosp Clin Univ Valladolid, Ctr Nacl Gripe Valladolid, Av Ramon y Cajal 3, Valladolid 47003, Spain
Diez Domingo, Javier
Redondo Marguello, Esther
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Ayuntamiento Madrid, Ctr Salud Int Madrid Salud, Madrid, SpainHosp Clin Univ Valladolid, Ctr Nacl Gripe Valladolid, Av Ramon y Cajal 3, Valladolid 47003, Spain