High-dose naltrexone and liver function safety

被引:0
|
作者
Marrazzi, MA
Wroblewski, JM
Kinzie, J
Luby, ED
机构
[1] WAYNE STATE UNIV,SCH MED,DEPT MED,DETROIT,MI 48201
[2] WAYNE STATE UNIV,SCH MED,DEPT PSYCHIAT,DETROIT,MI 48201
[3] HARPER GRACE HOSP,DEPT PSYCHIAT,DETROIT,MI 48201
[4] HARPER GRACE HOSP,DEPT MED,DETROIT,MI 48201
来源
AMERICAN JOURNAL ON ADDICTIONS | 1997年 / 6卷 / 01期
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中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Studies have found naltrexone useful in the treatment of diseases other than opiate addiction in which endogenous opioids presumably play a role, such as alcoholism and eating disorders. Some of these studies involve high doses (100-200 mg bid). Because investigational studies with high doses (300 mg/day) reported clinically significant increases in liver enzyme levels, the authors measured a spectrum of liver function parameters in response to high doses of naltrexone in a double-blind, crossover trial (100 mg bid) followed by an open-label period (200 mg bid). They observed no adverse clinical or laboratory changes in liver function in association with high-dose naltrexone therapy in eating disorders.
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页码:21 / 29
页数:9
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