Use of hemoglobin A1C to detect Haitian-Americans with undiagnosed Type 2 diabetes

被引：7

作者：

Exebio, Joel C. ^{[1
]}

Zarini, Gustavo G. ^{[1
]}

Vaccaro, Joan A. ^{[1
]}

Exebio, Cristobal ^{[2
]}

Huffman, Fatma G. ^{[1
]}

机构：

[1] Florida Int Univ, Dept Nutr & Dietet, Miami, FL 33199 USA

[2] Univ Privada Antenor Orrego, Dept Biostat, Trujillo, Peru

来源：

ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA | 2012年 / 56卷 / 07期

关键词：

Type; 2; diabetes; hemoglobin A1C; diagnosis; Haitians; FASTING PLASMA-GLUCOSE; HIGH-RISK; HBA(1C); FRUCTOSAMINE; PREVALENCE; TOLERANCE; CRITERIA;

D O I：

10.1590/S0004-27302012000700007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To evaluate the validity of hemoglobin A1C (A1C) as a diagnostic tool for type 2 diabetes and to determine the most appropriate A1C cutoff point for diagnosis in a sample of Haitian-Americans. Subjects and methods: Subjects (n = 128) were recruited from Miami-Dade and Broward counties, FL. Receiver operating characteristics (ROC) analysis was run in order to measure sensitivity and specificity of A1C for detecting diabetes at different cutoff points. Results: The area under the ROC curve was 0.86 using fasting plasma glucose >= 7.0 mmol/L as the gold standard. An A1C cutoff point of 6.26% had sensitivity of 80% and specificity of 74%, whereas an A1C cutoff point of 6.50% (recommended by the American Diabetes Association - ADA) had sensitivity of 73% and specificity of 89%. Conclusions: A1C is a reliable alternative to fasting plasma glucose in detecting diabetes in this sample of Haitian-Americans. A cutoff point of 6.26% was the optimum value to detect type 2 diabetes. Arq Bras Endocrinol Metab. 2012;56(7):449-55

引用

页码：449 / 455

页数：7

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