The Potential Role of Natural Killer Cells in the Treatment of Malignant Disease

被引：0

作者：

Handgretinger, Rupert ^{[1
]}

Pfeiffer, Matthias ^{[1
]}

Teltschik, Heiko-Manuel ^{[1
]}

Feuchtinger, Tobias ^{[1
]}

Mueller, Ingo ^{[1
]}

Lang, Peter ^{[1
]}

机构：

[1] Univ Tubingen, Univ Kinderklin, Abt 1, D-72076 Tubingen, Germany

来源：

PROGRESS AND CHALLENGES IN TRANSFUSION MEDICINE, HEMOSTASIS AND HEMOTHERAPY: STATE OF THE ART 2008 | 2008年

关键词：

Natural killer (NK) cells; Leukemia; Solid tumors; Killer Ig-like receptor (KIR); Cytotoxicity; Adoptive transfer;

D O I：

10.1159/000177289

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Since their discovery natural killer (NK) cells have been implicated in the control of tumor growth and metastasis in vivo. Originally described as large granular lymphocytes, INK cells are a heterogeneous population of lymphocytes with functional differences in terms of cytokine production and cytotoxicity. They express a variety of receptors which regulate their function and which allow them to recognize and eliminate tumor cells. Especially the discovery of inhibitory and activatory receptors for certain human leukocyte antigens has tremendously added insight into the role of NK cells in tumor surveillance, and the anti-tumor effect of alloreactive NK cells has been demonstrated in killer Ig-like receptor-mismatched allogeneic stem cell transplantion. The possibility to manipulate the balancing receptors and their ligands offers new perspectives of NK cell-based therapies, and the possibility to isolate NK cells in large numbers for clinical use allows the ex vivo activation and adoptive transfer of NK cells for treatment of various malignant diseases. (C) 2008 S. Karger GmbH, Freiburg i.Br.

引用

页码：352 / 362

页数：11

共 42 条

[1] A one-step large-scale method for T- and B-cell depletion of mobilized PBSC for allogeneic transplantation [J].

Barfield, RC ;

Otto, M ;

Houston, J ;

Holladay, M ;

Geiger, T ;

Martin, J ;

Leimig, T ;

Gordon, P ;

Chen, X ;

Handgretinger, R .

CYTOTHERAPY, 2004, 6 (01) :1-6

[2] Haploidentical allogeneic hematopoietic cell transplantation in adults using CD3/CD19 depletion and reduced intensity conditioning:: An update [J].

Bethge, Wolfgang A. ;

Faul, Christoph ;

Bornhaeuster, Martin ;

Stuhler, Gernot ;

Beelen, Dietrich W. ;

Lang, Peter ;

Stelljes, Matthias ;

Vogel, Wichard ;

Haegele, Matthias ;

Handgretinger, Rupert ;

Kanz, Lothar .

BLOOD CELLS MOLECULES AND DISEASES, 2008, 40 (01) :13-19

[3] Learning how to discriminate between friends and enemies, a lesson from Natural Killer cells [J].

Bottino, C ;

Moretta, L ;

Pende, D ;

Vitale, M ;

Moretta, A .

MOLECULAR IMMUNOLOGY, 2004, 41 (6-7) :569-575

[4] Natural killer cells, killer immunoglobulin-like receptors and human leucocyte antigen class I in disease [J].

Boyton, R. J. ;

Altmann, D. M. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2007, 149 (01) :1-8

[5] HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C [J].

Braud, VM ;

Allan, DSJ ;

O'Callaghan, CA ;

Söderström, K ;

D'Andrea, A ;

Ogg, GS ;

Lazetic, S ;

Young, NT ;

Bell, JI ;

Phillips, JH ;

Lanier, LL ;

McMichael, AJ .

NATURE, 1998, 391 (6669) :795-799

[6] NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer [J].

Cerwenka, A ;

Lanier, LL .

TISSUE ANTIGENS, 2003, 61 (05) :335-343

[7] A large-scale method for the selective depletion of αβ T lymphocytes from PBSC for allogeneic transplantation [J].

Chaleff, S. ;

Otto, M. ;

Barfield, R. C. ;

Leimig, T. ;

Iyengar, R. ;

Martin, J. ;

Holiday, M. ;

Houston, J. ;

Geiger, T. ;

Huppert, V. ;

Handgretinger, R. .

CYTOTHERAPY, 2007, 9 (08) :746-754

[8] The effect of KIR ligand incompatibility on the outcome of unrelated donor transplantation: A report from the Center for International Blood and Marrow Transplant Research, the European Blood and Marrow Transplant Registry, and the Dutch Registry [J].

Farag, Sherif S. ;

Bacigalupo, Andrea ;

Eapen, Mary ;

Hurley, Carolyn ;

Dupont, Bo ;

Caligiuri, Michael A. ;

Boudreau, Christian ;

Nelson, Gene ;

Oudshoorn, Machteld ;

van Rood, Jon ;

Velardi, Andrea ;

Maiers, Martin ;

Setterholm, Michelle ;

Confer, Dennis ;

Posch, Phillip E. ;

Anasetti, Claudio ;

Kamani, Naynesh ;

Miller, Effrey S. ;

Wiesdorf, Daniel ;

Davies, Stella M. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2006, 12 (08) :876-884

[9] Cytotoxic activity of natural killer cells lacking killer-inhibitory receptors for self-HLA class I molecules against autologous hernatopoietic stem cells in healthy individuals [J].

Grau, R ;

Lang, KS ;

Wernet, D ;

Lang, P ;

Niethammer, D ;

Pusch, CM ;

Handgretinger, R .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2004, 76 (02) :90-98

[10] Pure red-cell aplasia associated with clonal expansion of granular lymphocytes expressing killer-cell inhibitory receptors [J].

Handgretinger, R ;

Geiselhart, A ;

Moris, A ;

Grau, R ;

Teuffel, O ;

Bethge, W ;

Kanz, L ;

Fisch, P .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (04) :278-284

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