Construction of Protein Nanowires through Cucurbit[8]uril-based Highly Specific HostGuest Interactions: An Approach to the Assembly of Functional Proteins

被引：131

作者：

Hou, Chunxi ^{[1
]}

Li, Jiaxi ^{[1
]}

Zhao, Linlu ^{[1
]}

Zhang, Wei ^{[1
]}

Luo, Quan ^{[1
]}

Dong, Zeyuan ^{[1
]}

Xu, Jiayun ^{[1
]}

Liu, Junqiu ^{[1
]}

机构：

[1] Jilin Univ, Coll Chem, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 21期

关键词：

cucurbit[8]uril; host-guest systems; nanowires; proteins; self-assembly; TRANSFERASE;

D O I：

10.1002/anie.201300692

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Getting your proteins in a row: Self-assembled protein nanowires were designed by utilizing highly specific supramolecular interactions of cucurbit[8]uril (CB[8]) and a tripeptide FGG-tag attached on the N-termini of dimeric glutathione S-transferase (GST). With the aid of enzyme simulation, model protein GST was converted into a selenoenzyme glutathione peroxidase mimic, and the CB[8]-induced Se-FGG-GST(Y6C) nanowires demonstrated excellent antioxidative capacity. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5590 / 5593

页数：4

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