Umbilical Cord-Derived Mesenchymal Stem Cells for Hematopoietic Stem Cell Transplantation

被引：26
|
作者：
Chao, Yu-Hua [2 ,3 ]
Wu, Han-Ping [4 ]
Chan, Chin-Kan [5 ]
Tsai, Chris [6 ]
Peng, Ching-Tien [1 ,7 ,8 ]
Wu, Kang-Hsi [1 ,8 ]
机构：
[1] China Med Univ, Sch Chinese Med, Taichung, Taiwan
[2] Chung Shan Med Univ Hosp, Dept Pediat, Taichung, Taiwan
[3] Chung Shan Med Univ, Sch Med, Taichung, Taiwan
[4] Buddhist Tzu Chi Gen Hosp, Taichung Branch, Dept Pediat, Taichung, Taiwan
[5] Taoyuan Gen Hosp, Dept Pediat, Tao Yuan, Taiwan
[6] Bionet Corp, Taipei, Taiwan
[7] Asia Univ, Dept Biotechnol & Bioinformat, Taichung, Taiwan
[8] China Med Univ Hosp, Dept Pediat, Taichung, Taiwan
来源：
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2012年
关键词：
HUMAN BONE-MARROW; VERSUS-HOST-DISEASE; EX-VIVO EXPANSION; STROMAL CELLS; ENHANCE ENGRAFTMENT; PERIPHERAL-BLOOD; PROGENITOR CELLS; FETAL BLOOD; COTRANSPLANTATION; CULTURE;
D O I：
10.1155/2012/759503
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Hematopoietic stem cell transplantation (HSCT) is becoming an effective therapeutic modality for a variety of diseases. Mesenchymal stem cells (MSCs) can be used to enhance hematopoietic engraftment, accelerate lymphocyte recovery, reduce the risk of graft failure, prevent and treat graft-versus-host disease, and repair tissue damage in patients receiving HSCT. Till now, most MSCs for human clinical application have been derived from bone marrow. However, acquiring bone-marrow-derived MSCs involves an invasive procedure. Umbilical cord is rich with MSCs. Compared to bone-marrow-derived MSCs, umbilical cord-derived MSCs (UCMSCs) are easier to obtain without harm to the donor and can proliferate faster. No severe adverse effects were noted in our previous clinical application of UCMSCs in HSCT. Accordingly, application of UCMSCs in humans appears to be feasible and safe. Further studies are warranted.
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页数：5
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