Understanding the Impact of Subsidizing Artemisinin-Based Combination Therapies (ACTs) in the Retail Sector - Results from Focus Group Discussions in Rural Kenya

被引:12
作者
Kedenge, Sarah V. [1 ]
Kangwana, Beth P. [1 ]
Waweru, Evelyn W. [1 ]
Nyandigisi, Andrew J. [2 ]
Pandit, Jayesh [3 ]
Brooker, Simon J. [1 ,4 ]
Snow, Robert W. [1 ,5 ]
Goodman, Catherine A. [1 ,4 ]
机构
[1] Kenya Govt Med Res Ctr, Wellcome Trust Res Programme, Malaria Publ Hlth Grp, Nairobi, Kenya
[2] Minist Publ Hlth & Sanitat, Div Malaria Control, Nairobi, Kenya
[3] Pharm & Poisons Board, Nairobi, Kenya
[4] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England
[5] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England
基金
英国惠康基金;
关键词
LUMEFANTRINE TREATMENT POLICY; ARTEMETHER-LUMEFANTRINE; MALARIA TREATMENT; CASE-MANAGEMENT; 6-DOSE REGIMEN; GLOBAL SUBSIDY; AVAILABILITY; ADHERENCE; INTERVENTIONS; KNOWLEDGE;
D O I
10.1371/journal.pone.0054371
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: There is considerable interest in the potential of private sector subsidies to increase availability and affordability of artemisinin-based combination therapies (ACTs) for malaria treatment. A cluster randomized trial of such subsidies was conducted in 3 districts in Kenya, comprising provision of subsidized packs of paediatric ACT to retail outlets, training of retail staff, and community awareness activities. The results demonstrated a substantial increase in ACT availability and coverage, though patient counselling and adherence were suboptimal. We conducted a qualitative study in order to understand why these successes and limitations occurred. Methodology/Principal Findings: Eighteen focus group discussions were conducted, 9 with retailers and 9 with caregivers, to document experiences with the intervention. Respondents were positive about intervention components, praising the focused retailer training, affordable pricing, strong promotional activities, dispensing job aids, and consumer friendly packaging, which are likely to have contributed to the positive access and coverage outcomes observed. However, many retailers still did not stock ACT, due to insufficient supplies, lack of capital and staff turnover. Advice to caregivers was poor due to insufficient time, and poor recall of instructions. Adherence by caregivers to dosing guidelines was sub-optimal, because of a wish to save tablets for other episodes, doses being required at night, stopping treatment when the child felt better, and the number and bitter taste of the tablets. Caregivers used a number of strategies to obtain paediatric ACT for older age groups. Conclusions/Significance: This study has highlighted that important components of a successful ACT subsidy intervention are regular retailer training, affordable pricing, a reliable supply chain and community mobilization emphasizing patient adherence and when to seek further care.
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页数:10
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