Moving known libraries to an addressable array: A site-selective hetero-Michael reaction

被引：30

作者：

Stuart, Melissae ^{[1
]}

Maurer, Karl ^{[2
]}

Moeller, Kevin D. ^{[1
]}

机构：

[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA

[2] CombiMatrix Corp, Mukilteo, WA 98275 USA

来源：

BIOCONJUGATE CHEMISTRY | 2008年 / 19卷 / 08期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1021/bc800025z

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A two-step, Michael reaction-based strategy for site-selectively placing molecules by unique electrodes in an addressable microelectrode array has been developed. The strategy is compatible with the use of polypeptide nucleophiles and works with microelectrode arrays having either 1024 electrodes/cm(2) or 12 544 electrodes/cm(2). The chemistry should allow for the transfer of existinc, molecular libraries to microelectrode array devices for analysis.

引用

页码：1514 / 1517

页数：4