IgA nephropathy and IgA vasculitis with nephritis have a shared feature involving galactose-deficient IgA1-oriented pathogenesis

被引：198

作者：

Suzuki, Hitoshi ^{[1
]}

Yasutake, Junichi ^{[1
,2
]}

Makita, Yuko ^{[1
]}

Tanbo, Yuki ^{[1
,2
]}

Yamasaki, Kohei ^{[1
,2
]}

Sofue, Tadashi ^{[3
]}

Kano, Toshiki ^{[1
]}

Suzuki, Yusuke ^{[1
]}

机构：

[1] Juntendo Univ, Fac Med, Dept Nephrol, Tokyo, Japan

[2] Kyowa Hakko Kirin Co Ltd, Nephrol Res Labs, Tokyo, Japan

[3] Kagawa Univ, Fac Med, Dept CardioRenal & Cerebrovasc Med, Div Nephrol & Dialysis, Takamatsu, Kagawa, Japan

来源：

KIDNEY INTERNATIONAL | 2018年 / 93卷 / 03期

关键词：

IgA nephropathy; IgA vasculitis; renal biopsy; SCHONLEIN PURPURA NEPHRITIS; O-GLYCOSYLATION; ABERRANT GLYCOSYLATION;

D O I：

10.1016/j.kint.2017.10.019

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Galactose-deficient IgA1 has been proposed as an important effector molecule in IgA nephropathy (IgAN). We previously showed that the galactose-deficient IgA1-specific monoclonal antibody KM55 can detect circulating galactose-deficient IgA1 in patients with IgAN, enabling us to study the molecular roles of galactose-deficient IgA1. Herein, we further examined the pathophysiological significance of galactose-deficient IgA1 in glomerular deposits of patients with IgAN by immunohistochemistry using KM55. Immunostaining of galactose-deficient IgA1 with KM55 was performed in paraffin-embedded sections of renal biopsy specimens from 48 patients with IgAN and 49 patients with other renal diseases such as lupus nephritis, HCV-related nephropathy, IgA vasculitis with nephritis (IgA-VN), and membranous nephropathy. Glomerular galactose-deficient IgA1 was specifically detected in IgAN and IgA-VN but not in the other renal diseases. Galactose-deficient IgA1 was localized predominantly in the mesangial region as IgA deposition. However, galactose-deficient IgA1 was not detected in patients with lupus nephritis accompanied by glomerular IgA deposition. Thus, our study strongly suggests that IgAN and IgA-VN have a shared feature regarding galactose-deficient IgA1-oriented pathogenesis.

引用

页码：700 / 705

页数：6

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