The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion

被引：74

作者：

Evans, Anthony ^{[1
]}

Costello, Eithne ^{[1
,2
]}

机构：

[1] Univ Liverpool, Liverpool Canc Res UK Ctr, Liverpool L69 3BX, Merseyside, England

[2] Univ Liverpool, Natl Inst Hlth Res, Pancreas Biomed Res Unit, Dept Mol & Clin Canc,Med Ctr, Liverpool L69 3BX, Merseyside, England

来源：

FRONTIERS IN PHYSIOLOGY | 2012年 / 3卷

关键词：

mast cells; myeloid-derived suppressor cells; neutrophils; regulatory T cells; T helper cells; macrophages; inflammation; stroma; REGULATORY T-CELLS; MAST-CELLS; TUMOR MICROENVIRONMENT; PROGNOSTIC-FACTOR; SUPPRESSOR-CELLS; LYMPHOCYTE RATIO; DUCTAL ADENOCARCINORNA; MYELOID CELLS; MURINE MODEL; MACROPHAGE;

D O I：

10.3389/fphys.2012.00270

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The pancreatic ductal adenocarcinoma (PDAC) microenv ronment accommodates a variety of cell types and a plethora of complex interactions between tumor cells, host cells and extracellular matrix (ECM) components. Here we review the role of inflammatory cells, in particular mast cells, myeloid derived suppressor cells, macrophages, T regulatory cells, T helper cells and neutrophils. The picture that emerges is that of a tumor microenvironment, in which the immune response is actively suppressed, and inflammatory cells contribute in a variety of ways to tumor progression.

引用

页数：7

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