A calix[4]arene GdIII complex endowed with high stability, relaxivity, and binding affinity to serum albumin

被引：0

作者：

Aime, S

Barge, A

Botta, M

Casnati, A

Fragai, M

Luchinat, C

Ungaro, R

机构：

[1] Univ Piemonte Orientale Amedeo Avogadro, Dipartimento Sci & Tecnol Avanzate, I-15100 Alessandria, Italy

[2] Univ Parma, Dipartimento Chim Organ & Ind, I-43100 Parma, Italy

[3] Univ Turin, Dipartimento Chim IFM, I-10125 Turin, Italy

[4] Univ Florence, CERM, I-50019 Sesto Fiorentino, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2001年 / 40卷 / 24期

关键词：

calixarenes; contrast agents; coordination chemistry; lanthanides; NMR spectroscopy;

D O I：

10.1002/1521-3773(20011217)40:24<4737::AID-ANIE4737>3.0.CO;2-W

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Contrasting calixarenes: Thermodynamically stable and water-soluble calix[4]arene-LnIII (see picture) complexes may represent a new class of relaxation (Ln = Gd) or luminescent (Ln = Eu, Tb) probes for biomedical studies. The first complete characterization of one of these complexes in water is reported. The GdIII chelate shows a strong binding affinity with human serum albumin as a result of the cooperative effects of hydrophobic interaction and coordination by donors groups on the protein.

引用

页码：4737 / +

页数：4