A calix[4]arene GdIII complex endowed with high stability, relaxivity, and binding affinity to serum albumin

被引：0
|
作者：
Aime, S
Barge, A
Botta, M
Casnati, A
Fragai, M
Luchinat, C
Ungaro, R
机构：
[1] Univ Piemonte Orientale Amedeo Avogadro, Dipartimento Sci & Tecnol Avanzate, I-15100 Alessandria, Italy
[2] Univ Parma, Dipartimento Chim Organ & Ind, I-43100 Parma, Italy
[3] Univ Turin, Dipartimento Chim IFM, I-10125 Turin, Italy
[4] Univ Florence, CERM, I-50019 Sesto Fiorentino, Italy
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2001年 / 40卷 / 24期
关键词：
calixarenes; contrast agents; coordination chemistry; lanthanides; NMR spectroscopy;
D O I：
10.1002/1521-3773(20011217)40:24<4737::AID-ANIE4737>3.0.CO;2-W
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Contrasting calixarenes: Thermodynamically stable and water-soluble calix[4]arene-LnIII (see picture) complexes may represent a new class of relaxation (Ln = Gd) or luminescent (Ln = Eu, Tb) probes for biomedical studies. The first complete characterization of one of these complexes in water is reported. The GdIII chelate shows a strong binding affinity with human serum albumin as a result of the cooperative effects of hydrophobic interaction and coordination by donors groups on the protein.
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页码：4737 / +
页数：4
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