Cap-dependent, scanning-free translation initiation mechanisms

被引：60

作者：

Haimov, Ora ^{[1
]}

Sinvani, Hadar ^{[1
]}

Dikstein, Rivka ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2015年 / 1849卷 / 11期

基金：

欧盟地平线“2020”; 以色列科学基金会;

关键词：

Translation initiation; Protein synthesis; m7G cap; Cap-dependent; Scanning; Scanning-independent; EIFs; 5 ' UTR; Short 5 ' UTR; TISU; Ribosome; Ribosome shunt; ACTIVATED PROTEIN-KINASE; LOOP BINDING-PROTEIN; MESSENGER-RNA; STEM-LOOP; SKELETAL-MUSCLE; UPSTREAM AUGS; RIBOSOME; AMPK; TRANSCRIPTION; EXPRESSION;

D O I：

10.1016/j.bbagrm.2015.09.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eukaryotic translation initiation is an intricate and multi-step process that includes 43S Pre-Initiation Complex (PIC) assembly, attachment of the PIC to the mRNA, scanning, start codon selection and 60S subunit joining. Translation initiation of most mRNAs involves recognition of a 5'end m7G cap and ribosomal scanning in which the 5' UTR is checked for complementarity with the AUG. There is however an increasing number of mRNAs directing translation initiation that deviate from the predominant mechanism. In this review we summarize the canonical translation initiation process and describe non-canonical mechanisms that are cap-dependent but operate without scanning. In particular we focus on several examples of translation initiation driven either by mRNAs with extremely short 5' leaders or by highly complex 5' UTRs that promote ribosome shunting. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：1313 / 1318

页数：6

共 78 条

[1] A mechanistic overview of translation initiation in eukaryotes [J].

Aitken, Colin Echeverria ;

Lorsch, Jon R. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2012, 19 (06) :568-576

[2] Dynamics and processivity of 40S ribosome scanning on mRNA in yeast [J].

Berthelot, K ;

Muldoon, M ;

Rajkowitsch, L ;

Hughes, J ;

McCarthy, JEG .

MOLECULAR MICROBIOLOGY, 2004, 51 (04) :987-1001

[3] AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. [J].

Bolster, DR ;

Crozier, SJ ;

Kimball, SR ;

Jefferson, LS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (27) :23977-23980

[4] UNUSUAL GENE ORGANIZATION IN THE PROTOZOAN PARASITE ENTAMOEBA-HISTOLYTICA [J].

BRUCHHAUS, I ;

LEIPPE, M ;

LIOUTAS, C ;

TANNICH, E .

DNA AND CELL BIOLOGY, 1993, 12 (10) :925-933

[5] SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein [J].

Cakmakci, Nihal G. ;

Lerner, Rachel S. ;

Wagner, Eric J. ;

Zheng, Lianxing ;

Marzluff, William F. .

MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (03) :1182-1194

[6] Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans [J].

Calvo, Sarah E. ;

Pagliarini, David J. ;

Mootha, Vamsi K. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (18) :7507-7512

[7] Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle [J].

Canto, Carles ;

Jiang, Lake Q. ;

Deshmukh, Atul S. ;

Mataki, Chikage ;

Coste, Agnes ;

Lagouge, Marie ;

Zierath, Juleen R. ;

Auwerx, Johan .

CELL METABOLISM, 2010, 11 (03) :213-219

[8] Ribosomal shunting mediated by a translational enhancer element that base pairs to 18S rRNA [J].

Chappell, Stephen A. ;

Dresios, John ;

Edelman, Gerald M. ;

Mauro, Vincent P. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (25) :9488-9493

[9] Requirement of the DEAD-box protein Ded1p for messenger RNA translation [J].

Chuang, RY ;

Weaver, PL ;

Liu, Z ;

Chang, TH .

SCIENCE, 1997, 275 (5305) :1468-1471

[10] TRANSFER RNA(IMET) FUNCTIONS IN DIRECTING THE SCANNING RIBOSOME TO THE START SITE OF TRANSLATION [J].

CIGAN, AM ;

FENG, L ;

DONAHUE, TF .

SCIENCE, 1988, 242 (4875) :93-97

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