Carbapenem susceptibilities and non-susceptibility concordance to different carbapenems amongst clinically important Gram-negative bacteria isolated from intensive care units in Taiwan: Results from the Surveillance of Multicentre Antimicrobial Resistance in Taiwan (SMART) in 2009

被引：26

作者：

Jean, Shio-Shin ^{[1
]}

Hsueh, Po-Ren ^{[2
,3
]}

Lee, Wen-Sen ^{[4
]}

Yu, Kwok-Woon ^{[5
]}

Liao, Chun-Hsing ^{[6
]}

Chang, Feng-Yi ^{[7
]}

Ko, Wen-Chien ^{[8
]}

Wu, Jiunn-Jong ^{[9
]}

Chen, Yen-Hsu ^{[10
,11
]}

Chen, Yao-Shen ^{[12
]}

Liu, Jien-Wei ^{[13
]}

Lu, Min-Chi ^{[14
]}

Liu, Cheng-Yi ^{[15
]}

Lam, Carlos ^{[1
]}

Chen, Ray-Jade ^{[16
]}

机构：

[1] Taipei Med Univ, Wan Fang Hosp, Dept Emergency Med, Taipei, Taiwan

[2] Natl Taiwan Univ Coll Med, Natl Taiwan Univ Hosp, Dept Lab Med, Taipei 100, Taiwan

[3] Natl Taiwan Univ Coll Med, Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

[4] Taipei Med Univ, Wan Fang Hosp, Dept Internal Med, Div Infect Dis, Taipei, Taiwan

[5] Natl Yang Ming Univ, Taipei Vet Gen Hosp, Dept Internal Med Pathol & Lab Med, Taipei 112, Taiwan

[6] Far Eastern Mem Hosp, Dept Internal Med, Taipei, Taiwan

[7] NDMC, Triserv Gen Hosp, Dept Internal Med, Taipei, Taiwan

[8] Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan 70428, Taiwan

[9] Natl Cheng Kung Univ Coll Med, Sch Med Technol, Tainan, Taiwan

[10] Kaohsiung Med Univ Hosp, Dept Internal Med, Kaohsiung, Taiwan

[11] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan

[12] Kaohsiung Vet Gen Hosp, Dept Internal Med, Kaohsiung, Taiwan

[13] Chang Gung Med Coll, Kaohsiung Chang Gung Mem Hosp, Dept Internal Med, Kaohsiung, Taiwan

[14] Chung Shan Med & Dent Univ, Dept Lab Med & Internal Med, Taichung, Taiwan

[15] Taipei Vet Gen Hosp, Dept Internal Med, Div Infect Dis, Taipei, Taiwan

[16] Taipei Med Univ, Wan Fang Hosp, Dept Emergency & Crit Care Med, Taipei, Taiwan

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2013年 / 41卷 / 05期

关键词：

Carbapenem; Non-susceptibility; Enterobacteriaceae; Acinetobacter baumannii; Clinical and Laboratory Standards Institute; INTRAABDOMINAL INFECTIONS; KLEBSIELLA; MECHANISMS; OUTBREAK;

D O I：

10.1016/j.ijantimicag.2013.02.001

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

To investigate the in vitro susceptibilities to various carbapenems amongst clinical Gram-negative bacteria isolated from patients in intensive care units of ten major teaching hospitals in Taiwan in 2009, a survey was conducted to determine the minimum inhibitory concentrations (MICs) of ertapenem, imipenem, meropenem and doripenem against isolates of Enterobacteriaceae (n = 594), Pseudomonas aeruginosa (n = 185), Acinetobacter baumannii (n = 192) and Burkholderia cepacia (n = 23) using the agar dilution method. Susceptibilities were determined according to 2009, 2011 and 2012 MIC breakpoints recommended by the CLSI as well as 2012 MIC breakpoints recommended by EUCAST. Based on CLSI 2012 criteria, the ertapenem susceptible rate was 93%, 81%, 68% and 92% for Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae and Serratia marcescens, respectively. All Proteus mirabilis and Morganella morganii isolates were susceptible to ertapenem; however, 64% of P. mirabilis and all M. morganii isolates were non-susceptible to imipenem. Meropenem and doripenem had better activities than imipenem against ertapenem-non-susceptible Enterobacteriaceae isolates. E. coli, K. pneumoniae and E. cloacae with ertapenem MICs >= 4 mg/L were synchronously not susceptible to imipenem, meropenem and doripenem. Imipenem susceptibility was 65% and 29% for P. aeruginosa and A. baumannii, respectively. Additionally, P. aeruginosa and A. baumannii isolates with imipenem MICs >= 8 mg/L were also not susceptible to meropenem and doripenem. These data provide a better understanding of choosing appropriate carbapenem agents to treat infections caused by ertapenem-non-susceptible Enterobacteriaceae as well as P. aeruginosa and A. baumannii isolates with imipenem MICs >= 4 mg/L. (C) 2013 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：457 / 462

页数：6

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