Gastric Neuroendocrine Tumors in Our Institutions According to the WHO 2010 Classification

被引:16
作者
Endo, Shunji [1 ,3 ]
Dousei, Tsutomu [1 ]
Yoshikawa, Yukinobu [3 ]
Hatanaka, Nobutaka [3 ]
Taniyama, Kiyomi [4 ]
Yamauchi, Amane [2 ]
Kamiike, Wataru [3 ]
Nishijima, Junichi [1 ]
机构
[1] Higashiosaka City Gen Hosp, Dept Surg, Higashiosaka, Osaka 5788588, Japan
[2] Higashiosaka City Gen Hosp, Dept Diagnost Pathol, Higashiosaka, Osaka 5788588, Japan
[3] Natl Hosp Org, Kure Med Ctr, Chugoku Canc Ctr, Dept Surg, Kure, Hiroshima, Japan
[4] Natl Hosp Org, Kure Med Ctr, Chugoku Canc Ctr, Inst Clin Res, Kure, Hiroshima, Japan
关键词
Stomach neoplasms; Neuroendocrine tumors; Carcinoid tumor; Neuroendocrine carcinoma; Small cell carcinoma; Gastrin; Mitosis; Ki-67; antigen; Gastrectomy; World Health Organization; GUIDELINES; CARCINOMA; STOMACH;
D O I
10.9738/CC134.1
中图分类号
R61 [外科手术学];
学科分类号
摘要
In 2010, World Health Organization classified gastric neuroendocrine tumor (NET) as follows: NET grade (G) 1, NET G2, neuroendocrine carcinoma (NEC). We reviewed 22 gastric NETs that were encountered in our institutions. Nine, 6, and 4 were NET G1, G2, and NEC, respectively. We also encountered 3 NET G3. NET G1 was treated with observation in 2 patients, endoscopic mucosal resection (EMR) in 3, and gastrectomy in 4 patients. No recurrence was experienced during a median of 53 months of follow-up. All NET G2 was treated with gastrectomy. No patient experienced recurrence during a median of 25 months of follow-up. NET G3 was treated with gastrectomy. One patient died of liver metastasis 52 months after gastrectomy. For NEC, gastrectomy was performed in 3 cases and no patients died of tumor-related death. We conclude that the prognoses of NET G1 and G2 were good. We also experienced long-term survivors of NEC. An accumulation of more patients is needed for further investigation.
引用
收藏
页码:335 / 339
页数:5
相关论文
共 8 条
[1]   NANETS Treatment Guidelines Well-Differentiated Neuroendocrine Tumors of the Stomach and Pancreas [J].
Kulke, Matthew H. ;
Anthony, Lowell B. ;
Bushnell, David L. ;
de Herder, Wouter W. ;
Goldsmith, Stanley J. ;
Klimstra, David S. ;
Marx, Stephen J. ;
Pasieka, Janice L. ;
Pommier, Rodney F. ;
Yao, James C. ;
Jensen, Robert T. .
PANCREAS, 2010, 39 (06) :735-752
[2]  
*NAT COMPR CANC NE, NCCN GUID VERS 1 201
[3]   3 SUBTYPES OF GASTRIC ARGYROPHIL CARCINOID AND THE GASTRIC NEUROENDOCRINE CARCINOMA - A CLINICOPATHOLOGICAL STUDY [J].
RINDI, G ;
LUINETTI, O ;
CORNAGGIA, M ;
CAPELLA, C ;
SOLCIA, E .
GASTROENTEROLOGY, 1993, 104 (04) :994-1006
[4]   ECL cell tumor and poorly differentiated endocrine carcinoma of the stomach: Prognostic evaluation by pathological analysis [J].
Rindi, G ;
Azzoni, C ;
La Rosa, S ;
Klersy, C ;
Paolotti, D ;
Rappel, S ;
Stolte, M ;
Capella, C ;
Bordi, C ;
Solcia, E .
GASTROENTEROLOGY, 1999, 116 (03) :532-542
[5]  
Rindi G., 2010, WHO classification of tumors of the digestive system
[6]  
Sobin LH., 2011, TNM classification of malignant tumours
[7]  
Solcia E, 2000, HISTOLOGICAL TYPING OF ENDOCRINE TUMOURS, 2ND EDITION, P61
[8]   The NANETS Consensus Guidelines for the Diagnosis and Management of Poorly Differentiated (High-Grade) Extrapulmonary Neuroendocrine Carcinomas [J].
Strosberg, Jonathan R. ;
Coppola, Domenico ;
Klimstra, David S. ;
Phan, Alexandria T. ;
Kulke, Matthew H. ;
Wiseman, Gregory A. ;
Kvols, Larry K. .
PANCREAS, 2010, 39 (06) :799-800