The role of mass spectrometry in the analysis of vitamin D compounds

被引：29
作者：
Gathungu, Rose M. [1 ]
Flarakos, Caroline C. [1 ]
Reddy, G. Satyanarayana [2 ,3 ]
Vouros, Paul [1 ]
机构：
[1] Northeastern Univ, Barnett Inst Chem & Biol Anal, Dept Chem & Chem Biol, Boston, MA 02115 USA
[2] Epimer LLC, Smithfield, RI USA
[3] Brown Univ, Dept Chem, Providence, RI 02912 USA
来源：
MASS SPECTROMETRY REVIEWS | 2013年 / 32卷 / 01期
关键词：
1a; 25-dihydroxyvitamin D3; 25 dihydroxy-3-epi vitamin D3; vitamin D analogs; LC-MS; MS; GC-MS; C-24 OXIDATION PATHWAY; PERFORMANCE LIQUID-CHROMATOGRAPHY; D ENDOCRINE SYSTEM; CALCITRIOL 1,25-DIHYDROXYVITAMIN D-3; C-3 EPIMERIZATION PATHWAY; D METABOLITES; 1-ALPHA; 25-DIHYDROXY-3-EPI-VITAMIN D-3; 25-HYDROXYVITAMIN D-3; HUMAN KERATINOCYTES; BIOLOGICAL-ACTIVITY;
D O I：
10.1002/mas.21353
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
This review highlights the superseding role of mass spectrometry in the structural characterization and quantitation of vitamin D compounds in comparison to other analytical methods (e.g., UV, bioassays) that lack the sensitivity and specificity of mass spectrometry. After a short introduction to the biochemistry of vitamin D compounds, an overview of the current techniques to characterize and quantitate vitamin D compounds is given with emphasis on the contribution of mass spectrometry. (c) 2012 Wiley Periodicals, Inc., Mass Spec Rev 32:7286, 2013
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页码：72 / 86
页数：15
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