Abnormal folate metabolism in mothers with Down syndrome offspring: Review of the literature

被引：36

作者：

Eskes, TKAB ^{[1
]}

机构：

[1] Univ Nijmegen, Med Ctr St Radboud, NL-6500 HB Nijmegen, Netherlands

来源：

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 2006年 / 124卷 / 02期

关键词：

folate; genetic mutations; Down syndrome;

D O I：

10.1016/j.ejogrb.2005.07.028

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Altered maternal folate status and homozygous mutation in the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes can promote chromosomal instability and non-dysjunction resulting in fetal trisomy 21. Folate supplementation around conception therefore has the potential to reduce the frequency of Down syndrome. This finding, in addition to the prevention of neural tube defects, strengthens the recommendation to use folic acid around conception. (c) 2005 Published by Elsevier Ireland Ltd.

引用

页码：130 / 133

页数：4

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