Antiviral agents. I. Synthesis and antiviral evaluation of trimeric naphthoquinone analogues of conocurvone

被引：21

作者：

Crosby, Ian T. ^{[1
]}

Rose, Mark L. ^{[1
]}

Collis, Maree P. ^{[2
]}

de Bruyn, Paula J. ^{[1
]}

Keep, Philip L. C. ^{[2
]}

Robertson, Alan D. ^{[2
]}

机构：

[1] Monash Univ, Monash Inst Pharmaceut Sci, Parkville, Vic 3052, Australia

[2] AMRAD Operat Pty Ltd, Richmond, Vic 3121, Australia

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2008年 / 61卷 / 10期

关键词：

D O I：

10.1071/CH08177

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Conocurvone, a novel natural product isolated from the endemic Australian shrub Conosperum sp. (Proteaceae), exhibits anti-HIV activity but is a highly lipophilic compound, which suggests that there may be problems with its aqueous solubility and bioavailability. A general and convenient synthesis of trimeric naphthoquinones using the condensation of 2-hydroxynaphthoquinones and 2,3-dihaloquinones is described. The application of this method to the synthesis of a series of simpler and less lipophilic trimeric naphthoquinone simple analogues of conocurvone is also reported together with their anti-HIV activity.

引用

页码：768 / 784

页数：17

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