Optimum design of family structure and allocation of resources in association mapping with lines from multiple crosses

被引:26
作者
Liu, W. [1 ,2 ]
Maurer, H. P. [2 ]
Reif, J. C. [2 ]
Melchinger, A. E. [3 ]
Utz, H. F. [3 ]
Tucker, M. R. [4 ]
Ranc, N. [5 ]
Della Porta, G. [6 ]
Wuerschum, T. [2 ]
机构
[1] China Agr Univ, Crop Genet & Breeding Dept, Beijing 100094, Peoples R China
[2] Univ Hohenheim, State Plant Breeding Inst, D-70599 Stuttgart, Germany
[3] Univ Hohenheim, Inst Plant Breeding Seed Sci & Populat Genet, D-70599 Stuttgart, Germany
[4] Univ Adelaide, ARC Ctr Excellence Plant Cell Walls, Urrbrae, SA, Australia
[5] Syngenta Seeds SAS, St Sauveur, France
[6] Syngenta Seeds SpA, Casalmorano, Italy
关键词
QUANTITATIVE TRAIT LOCI; GENETIC ARCHITECTURE; COMPLEX TRAITS; JOINT LINKAGE; QTL DETECTION; MAIZE; POWER; POPULATIONS; EFFICIENCY; SELECTION;
D O I
10.1038/hdy.2012.63
中图分类号
Q14 [生态学(生物生态学)];
学科分类号
071012 ; 0713 ;
摘要
Family mapping is based on multiple segregating families and is becoming increasingly popular because of its advantages over population mapping. Athough much progress has been made recently, the optimum design and allocation of resources for family mapping remains unclear. Here, we addressed these issues using a simulation study, resample model averaging and cross-validation approaches. Our results show that in family mapping, the predictive power and the accuracy of quatitative trait loci (QTL) detection depend greatly on the population size and phenotyping intensity. With small population sizes or few test environments, QTL results become unreliable and are hampered by a large bias in the estimation of the proportion of genotypic variance explained by the detected QTL. In addition, we observed that even though good results can be achieved with low marker densities, no plateau is reached with our full marker complement. This suggests that higher quality results could be achieved with greater marker densities or sequence data, which will be available in the near future for many species. Heredity (2013) 110, 71-79; doi:10.1038/hdy.2012.63; published online 10 October 2012
引用
收藏
页码:71 / 79
页数:9
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