Development ofin vitro2D and 3D microelectrode arrays and their role in advancing biomedical research

被引：40

作者：

Didier, Charles M. ^{[1
,2
]}

Kundu, Avra ^{[1
]}

DeRoo, David ^{[1
]}

Rajaraman, Swaminathan ^{[1
,2
,3
,4
]}

机构：

[1] Univ Cent Florida, NanoSci Technol Ctr, 4353 Scorpius St,Res 1,Suite 231, Orlando, FL 32816 USA

[2] Univ Cent Florida, Burnett Sch Biomed Sci, 6900 Lake Nona Blvd, Orlando, FL 32827 USA

[3] Univ Cent Florida, Dept Mat Sci & Engn, 12760 Pegasus Dr,Engn 1,Suite 207, Orlando, FL 32816 USA

[4] Univ Cent Florida, Dept Elect & Comp Engn, 4238 Scorpius St, Orlando, FL 32816 USA

来源：

JOURNAL OF MICROMECHANICS AND MICROENGINEERING | 2020年 / 30卷 / 10期

关键词：

planar microelectrode arrays; three-dimensional microelectrode arrays; electrogenic cell applications; in vitroassays; ON-A-CHIP; CELL-DERIVED CARDIOMYOCYTES; PLURIPOTENT STEM-CELLS; PATCH-CLAMP TECHNIQUES; IN-VITRO; MULTIELECTRODE ARRAY; ELECTROGENIC CELLS; NEURONAL NETWORKS; DRUG DISCOVERY; ANIMAL-MODELS;

D O I：

10.1088/1361-6439/ab8e91

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

The development of microelectrode arrays (MEAs) along with complementary advances in electronics, mechanics and software to connect with these arrays has led to thein vitrointerfacing and benchtop electrophysiological models of several electrically active cells such as neurons and cardiomyocytes proving vital models and testing of human disease conditions in a dish/on a chip. This topical review deals with the micro/nanofabrication technology development of Microelectrodes Arrays from early silicon based developments to today's additive manufacturing technologies that have been employed to address bio-micro-electro-mechanical systems tool development in this space. Specifically 2D and 3D MEAs technologies have been reviewed in this paper along with a broad overview of some of the biological applications using these devices that are advancing the very state of biomedical research.

引用

页数：28

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