Beta-Blockers: Current State of Knowledge and Perspectives

被引：35
|
作者：
Ogrodowczyk, Magdalena [1 ]
Dettlaff, Katarzyna [1 ]
Jelinska, Anna [1 ]
机构：
[1] Poznan Univ Med Sci, Dept Pharmaceut Chem, PL-60780 Poznan, Poland
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2016年 / 16卷 / 01期
关键词：
Activity; application; aryloxyaminopropanol derivatives; beta-blockers; structure; LEFT-VENTRICULAR DYSFUNCTION; ACUTE MYOCARDIAL-INFARCTION; CONGESTIVE-HEART-FAILURE; DILATED CARDIOMYOPATHY; ANTIOXIDANT ACTIVITY; ADRENOLYTIC ACTIVITY; ELDERLY-PATIENTS; CARVEDILOL; GLAUCOMA; THERAPY;
D O I：
10.2174/1389557515666151016125948
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
It has been over half a century since propranolol, the first beta-blocker, was developed for medical treatment. Since that time a large number of compounds from this group have been synthesised and many are now in clinical use. The structure, function, pharmacokinetics, and mechanism of beta-blockers have been established. The possibilities for their use in treating different conditions continue to evolve. Since the discovery of later generation beta-blockers, such as carvedilol and nebivolol, the search for new compounds continues, and may include known substances with beta-blocking properties which could extend their therapeutic potential.
引用
收藏
页码：40 / 54
页数：15
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