Molecular docking analysis of Plasmodium falciparum dihydroorotate dehydrogenase towards the design of effective inhibitors

被引：4
|
作者：
Owoloye, Afolabi [1 ,2 ]
Enejoh, Ojochenemi A. [2 ]
Akanbi, Olusegun M. [1 ]
Bankole, Owolabi M. [2 ,3 ]
机构：
[1] Adekunle Ajasin Univ, Dept Anim & Environm Biol, Parasitol Unit, Akungba Akoko, Nigeria
[2] Adekunle Ajasin Univ, Ctr Biocomp & Drug Dev, Akungba Akoko, Nigeria
[3] Adekunle Ajasin Univ, Dept Chem, Akungba Akoko, Nigeria
来源：
BIOINFORMATION | 2020年 / 16卷 / 09期
关键词：
Plasmodium falciparum; dihydroorotate dehydrogenase; rosmarinic acid; catechin; deoxykaempferol; chloroquine; MALARIA;
D O I：
10.6026/97320630016672
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Malaria remains a global public health burden with significant mortality and morbidity. Despite the several approved drugs available for its management, the parasite has developed resistance to virtually all known antimalarial drugs. The development of a new drug that can combat resistant to Artemisinin based Combination Therapies (ACTs) for malaria is imperative. Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH), a flavin-dependent mitochondrial enzyme is vital in the parasite's pyrimidine biosynthesis is a well-known drug target. Therefore, it is of interest to document the MOLECULAR DOCKING analysis (using Maestro, Schrodinger) data of DIHYDROOROTATE DEHYDROGENASE PfDHODH from P. falciparum towards the design of effective inhibitors. The molecular docking features of 10 compounds with reference to chloroquine with PfDHODH are documented in this report for further consideration.
引用
收藏
页码：672 / 678
页数：7
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