Lycium barbarum L. Polysaccharide (LBP) Reduces Glucose Uptake via Down-Regulation of SGLT-1 in Caco2 Cell

被引：47

作者：

Cai, Huizhen ^{[1
]}

Yang, Xiaohui ^{[2
]}

Cai, Qian ^{[3
]}

Ren, Binbin ^{[3
]}

Qiu, Hongyan ^{[4
]}

Yao, Zhiqing ^{[1
]}

机构：

[1] Ningxia Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Ningxia 750004, Peoples R China

[2] Ningxia Med Univ, Sch Publ Hlth, Dept Sanit Chem, Ningxia 750004, Peoples R China

[3] Ningxia Med Univ, Sch Publ Hlth, Dept Expt Ctr, Ningxia 750004, Peoples R China

[4] Ningxia Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Ningxia 750004, Peoples R China

来源：

MOLECULES | 2017年 / 22卷 / 02期

关键词：

Lycium barbarum L; polysaccharide; Caco2 cell monolayer; SGLT-1; GLUT-2; IN-VITRO; DIGESTION; SYSTEM; MODEL; LINE;

D O I：

10.3390/molecules22020341

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lycium barbarum L. polysaccharide (LBP) is prepared from Lycium barbarum L. (L. barbarum), which is a traditional Chinese medicine. LPB has been shown to have hypoglycemic effects. In order to gain some mechanistic insights on the hypoglycemic effects of LBP, we investigated the uptake of LBP and its effect on glucose absorption in the human intestinal epithelial cell line Caco2 cell. The uptake of LBP through Caco2 cell monolayer was time-dependent and was inhibited by phloridzin, a competitive inhibitor of SGLT-1. LPB decreased the absorption of glucose in Caco2 cell, and down-regulated the expression of SGLT-1. These results suggest that LBP might be transported across the human intestinal epithelium through SGLT-1 and it inhibits glucose uptake via down-regulating SGLT-1.

引用

页数：12

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