Stimulation-induced parkinsonism after posteroventral deep brain stimulation of the globus pallidus internus for craniocervical dystonia

被引:51
作者
Zauber, S. Elizabeth [1 ]
Watson, Nidhi
Comella, Cynthia L. [1 ]
Bakay, Roy A. E. [2 ]
Metman, Leo Verhagen [1 ]
机构
[1] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA
[2] Rush Univ, Med Ctr, Dept Neurosurg, Chicago, IL 60612 USA
基金
美国国家卫生研究院;
关键词
deep brain stimulation; dystonia; globus pallidus internus; parkinsonism; PRIMARY GENERALIZED DYSTONIA; PEDUNCULOPONTINE NUCLEUS; DISEASE;
D O I
10.3171/2008.6.17621
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The authors report on a patient with craniocervical dystonia who was treated with bilateral GPi stimulation, with excellent improvement in dystonia but at the cost of stimulation-induced, reversible parkinsonism. Stimulation through ventral contacts resulted in maximal relief of craniocervical dystonia but induced considerable hypophonia, bradykinesia, rigidity, freezing, and impaired postural reflexes. Stimulation through dorsal contacts alleviated parkinsonism, but resulted in the return of dystonia. No stimulation parameters could alleviate the dystonia without inducing parkinsonism over the course of his 4-year follow-up. (DOI: 10.3171/2008.6.17621)
引用
收藏
页码:229 / 233
页数:5
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