Pembrolizumab as first-line treatment for non-small cell lung cancer-a game changer?

被引：4

作者：

Dempke, Wolfram C. M. ^{[1
,2
]}

Fenchel, Klaus ^{[3
]}

机构：

[1] Kyowa Kirin Pharmaceut Dev Ltd, Dept Med Oncol, Galabank Business Pk, Galashiels TD1 1QH, Scotland

[2] Univ Munich, Univ Hosp Grosshadern, Dept Haematol & Oncol, Munich, Germany

[3] Med Sch Hamburg, Dept Med, Hamburg, Germany

来源：

TRANSLATIONAL LUNG CANCER RESEARCH | 2016年 / 5卷 / 05期

关键词：

PHASE-III; NIVOLUMAB; CHEMOTHERAPY; DOCETAXEL; CISPLATIN;

D O I：

10.21037/tlcr.2016.10.01

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：538 / 542

页数：5

共 17 条

[1] Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer [J].

Borghaei, H. ;

Paz-Ares, L. ;

Horn, L. ;

Spigel, D. R. ;

Steins, M. ;

Ready, N. E. ;

Chow, L. Q. ;

Vokes, E. E. ;

Felip, E. ;

Holgado, E. ;

Barlesi, F. ;

Kohlhaeufl, M. ;

Arrieta, O. ;

Burgio, M. A. ;

Fayette, J. ;

Lena, H. ;

Poddubskaya, E. ;

Gerber, D. E. ;

Gettinger, S. N. ;

Rudin, C. M. ;

Rizvi, N. ;

Crino, L. ;

Blumenschein, G. R. ;

Antonia, S. J. ;

Dorange, C. ;

Harbison, C. T. ;

Finckenstein, F. Graf ;

Brahmer, J. R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (17) :1627-1639

[2] Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer [J].

Brahmer, Julie ;

Reckamp, Karen L. ;

Baas, Paul ;

Crino, Lucio ;

Eberhardt, Wilfried E. E. ;

Poddubskaya, Elena ;

Antonia, Scott ;

Pluzanski, Adam ;

Vokes, Everett E. ;

Holgado, Esther ;

Waterhouse, David ;

Ready, Neal ;

Gainor, Justin ;

Aren Frontera, Osvaldo ;

Havel, Libor ;

Steins, Martin ;

Garassino, Marina C. ;

Aerts, Joachim G. ;

Domine, Manuel ;

Paz-Ares, Luis ;

Reck, Martin ;

Baudelet, Christine ;

Harbison, Christopher T. ;

Lestini, Brian ;

Spigel, David R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (02) :123-135

[3]

Dempke WCM, 2015, ANTICANCER RES, V35, P5745

[4] Moving Programmed Death-1 Inhibitors to the Front Lines in Non-Small-Cell Lung Cancer [J].

Gainor, Justin F. .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (25) :2953-+

[5] Pembrolizumab for the Treatment of Non-Small-Cell Lung Cancer [J].

Garon, Edward B. ;

Rizvi, Naiyer A. ;

Hui, Rina ;

Leighl, Natasha ;

Balmanoukian, Ani S. ;

Eder, Joseph Paul ;

Patnaik, Amita ;

Aggarwal, Charu ;

Gubens, Matthew ;

Horn, Leora ;

Carcereny, Enric ;

Ahn, Myung-Ju ;

Felip, Enriqueta ;

Lee, Jong-Seok ;

Hellmann, Matthew D. ;

Hamid, Omid ;

Goldman, Jonathan W. ;

Soria, Jean-Charles ;

Dolled-Filhart, Marisa ;

Rutledge, Ruth Z. ;

Zhang, Jin ;

Lunceford, Jared K. ;

Rangwala, Reshma ;

Lubiniecki, Gregory M. ;

Roach, Charlotte ;

Emancipator, Kenneth ;

Gandhi, Leena .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (21) :2018-2028

[6] Nivolumab Monotherapy for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer [J].

Gettinger, Scott ;

Rizvi, Naiyer A. ;

Chow, Laura Q. ;

Borghaei, Hossein ;

Brahmer, Julie ;

Ready, Neal ;

Gerber, David E. ;

Shepherd, Frances A. ;

Antonia, Scott ;

Goldman, JonathanW. ;

Juergens, Rosalyn A. ;

Laurie, Scott A. ;

Nathan, Faith E. ;

Shen, Yun ;

Harbison, Christopher T. ;

Hellmann, Matthew D. .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (25) :2980-+

[7] Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial [J].

Herbst, Roy S. ;

Baas, Paul ;

Kim, Dong-Wan ;

Felip, Enriqueta ;

Perez-Gracia, Jose L. ;

Han, Ji-Youn ;

Molina, Julian ;

Kim, Joo-Hang ;

Arvis, Catherine Dubos ;

Ahn, Myung-Ju ;

Majem, Margarita ;

Fidler, Mary J. ;

de Castro, Gilberto, Jr. ;

Garrido, Marcelo ;

Lubiniecki, Gregory M. ;

Shentu, Yue ;

Im, Ellie ;

Dolled-Filhart, Marisa ;

Garon, Edward B. .

LANCET, 2016, 387 (10027) :1540-1550

[8] Advances in the Treatment of Non-small Cell Lung Cancer: Focus on Nivolumab, Pembrolizumab, and Atezolizumab [J].

Leventakos, Konstantinos ;

Mansfield, Aaron S. .

BIODRUGS, 2016, 30 (05) :397-405

[9] PARAMOUNT: Final Overall Survival Results of the Phase III Study of Maintenance Pemetrexed Versus Placebo Immediately After Induction Treatment With Pemetrexed Plus Cisplatin for Advanced Nonsquamous Non-Small-Cell Lung Cancer [J].

Paz-Ares, Luis G. ;

de Marinis, Filippo ;

Dediu, Mircea ;

Thomas, Michael ;

Pujol, Jean-Louis ;

Bidoli, Paolo ;

Molinier, Olivier ;

Sahoo, Tarini Prasad ;

Laack, Eckart ;

Reck, Martin ;

Corral, Jesus ;

Melemed, Symantha ;

John, William ;

Chouaki, Nadia ;

Zimmermann, Annamaria H. ;

Visseren-Grul, Carla ;

Gridelli, Cesare .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (23) :2895-+

[10] Systemic chemotherapy for advanced non-small cell lung cancer: Recent advances and future directions [J].

Ramalingam, Suresh ;

Belani, Chandra .

ONCOLOGIST, 2008, 13 :5-13

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