Therapeutic Angiogenesis A New Treatment Approach for Ischemic Heart Disease - Part I

被引：42

作者：

Ahn, Anna ^{[2
]}

Frishman, William H. ^{[1
]}

Gutwein, Andrew ^{[1
]}

Passeri, Jonathan ^{[3
]}

Nelson, Michael ^{[4
]}

机构：

[1] New York Med Coll, Dept Med, Westchester Med Ctr, Valhalla, NY 10595 USA

[2] Long Isl Jewish Med Ctr, Albert Einstein Coll Med, Dept Med, New Hyde Pk, NY 11042 USA

[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Med, Boston, MA USA

[4] Emory Univ, Dept Med, Med Ctr, Atlanta, GA 30322 USA

来源：

CARDIOLOGY IN REVIEW | 2008年 / 16卷 / 04期

关键词：

angiogenesis; angiogenic growth factors; vascular endothelial growth factor; fibroblast growth factor; myocardial ischemia; gene therapy;

D O I：

10.1097/CRD.0b013e3181620e3b

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Angiogenesis is the biologic process of forming new blood vessels and is being investigated as an innovative therapeutic approach to help manage ischemic heart disease and peripheral vascular disease. Research studies have identified various angiogenic growth factors and progenitor cells that can enhance new blood vessel formation. Preclinical investigations in animal models have explored the potential use of growth factors with and without progenitor cells to treat myocardial ischemia. The results of clinical trials with growth factor infusions and gene therapy techniques to enhance growth factor production have shown some promise, but therapeutic angiogenesis remains at an early stage of development.

引用

页码：163 / 171

页数：9

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