Two-Dimensional Manipulation of Magnetic Nanoparticles in Microfluidic Systems

被引:11
作者
Cao, Quanliang [1 ,2 ]
Han, Xiaotao [1 ,2 ]
Li, Liang [1 ,2 ]
机构
[1] Huazhong Univ Sci & Technol, Wuhan Natl High Magnet Field Ctr, Wuhan 430074, Peoples R China
[2] Huazhong Univ Sci & Technol, State Key Lab Adv Electromagnet Engn & Technol, Wuhan 430074, Peoples R China
基金
中国国家自然科学基金;
关键词
DRUG-DELIVERY; ON-CHIP;
D O I
10.7567/APEX.6.025201
中图分类号
O59 [应用物理学];
学科分类号
摘要
A magnetic manipulation technique based on a superimposed gradient magnetic field source for controlling magnetic nanoparticles in microfluidic channels was proposed. The designed magnetic field is composed of one gradient magnetic field generated by micro-electromagnetic coils positioned near a microfluidic channel and one external uniform magnetic field generated by large Helmholtz coil pairs. By controlling the configuration of Helmholtz coils, magnetic nanoparticles can be transported in different movement modes. As a proof of concept, the transport behavior of magnetic nanoparticles under different configurations of Helmholtz coils was successfully performed in two-dimensional (2D) geometries. (C) 2013 The Japan Society of Applied Physics
引用
收藏
页数:3
相关论文
共 21 条
[1]   A high field gradient magnet for magnetic drug targeting [J].
Alexiou, Christoph ;
Diehl, Dirk ;
Henninger, Peter ;
Iro, Heinrich ;
Roeckelein, Rudolf ;
Schmidt, Wolfgang ;
Weber, Horst .
IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY, 2006, 16 (02) :1527-1530
[2]   Applications of microelectromagnetic traps [J].
Basore, Joseph R. ;
Baker, Lane A. .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2012, 403 (08) :2077-2088
[3]   Progress in functionalization of magnetic nanoparticles for applications in biomedicine [J].
Berry, Catherine C. .
JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2009, 42 (22)
[4]   Numerical analysis of magnetic nanoparticle transport in microfluidic systems under the influence of permanent magnets [J].
Cao, Quanliang ;
Han, Xiaotao ;
Li, Liang .
JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2012, 45 (46)
[5]   Local control of magnetic objects in microfluidic channels [J].
Derec, Caroline ;
Wilhelm, Claire ;
Servais, Jacques ;
Bacri, Jean-Claude .
MICROFLUIDICS AND NANOFLUIDICS, 2010, 8 (01) :123-130
[6]   On chip magnetic actuator for batch-mode dynamic manipulation of magnetic particles in compact lab-on-chip [J].
Fulcrand, Remy ;
Bancaud, Aurelien ;
Escriba, Christophe ;
He, Qihao ;
Charlot, Samuel ;
Boukabache, Ali ;
Gue, Anne-Marie .
SENSORS AND ACTUATORS B-CHEMICAL, 2011, 160 (01) :1520-1528
[7]   Magnetic forces produced by rectangular permanent magnets in static microsystems [J].
Gassner, Anne-Laure ;
Abonnenc, Melanie ;
Chen, Hong-Xu ;
Morandini, Jacques ;
Josserand, Jacques ;
Rossier, Joel S. ;
Busnel, Jean-Marc ;
Girault, Hubert H. .
LAB ON A CHIP, 2009, 9 (16) :2356-2363
[8]   Magnetic bead handling on-chip: new opportunities for analytical applications [J].
Gijs, MAM .
MICROFLUIDICS AND NANOFLUIDICS, 2004, 1 (01) :22-40
[9]   Deep magnetic capture of magnetically loaded cells for spatially targeted therapeutics [J].
Huang, Zheyong ;
Pei, Ning ;
Wang, Yanyan ;
Xie, Xinxing ;
Sun, Aijun ;
Shen, Li ;
Zhang, Shuning ;
Liu, Xuebo ;
Zou, Yunzeng ;
Qian, Juying ;
Ge, Junbo .
BIOMATERIALS, 2010, 31 (08) :2130-2140
[10]   Microelectromagnets for the control of magnetic nanoparticles [J].
Lee, CS ;
Lee, H ;
Westervelt, RM .
APPLIED PHYSICS LETTERS, 2001, 79 (20) :3308-3310