Nicotinic acid inhibits NLRP3 inflammasome activation via SIRT1 in vascular endothelial cells

被引：19

作者：

Li, Yanxiang ^{[1
,2
]}

Yang, Guangde ^{[3
]}

Yang, Xiaofeng ^{[1
]}

Wang, Weirong ^{[4
]}

Zhang, Jiye ^{[3
]}

He, Yanhao ^{[1
]}

Zhang, Wei ^{[1
]}

Jing, Ting ^{[1
]}

Lin, Rong ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Dept Pharmacol, Hlth Sci Ctr, Xian 710061, Shaanxi, Peoples R China

[2] Taizhou Polytech Coll, Taizhou 225300, Jiangsu, Peoples R China

[3] Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Pharm, Xian 710061, Shaanxi, Peoples R China

[4] Xi An Jiao Tong Univ, Hlth Sci Ctr, Lab Anim Ctr, Xian 710061, Shaanxi, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2016年 / 40卷

基金：

中国国家自然科学基金;

关键词：

Nicotinic acid; NLRP3; inflammasome; SIRT1; ROS; SMOOTH-MUSCLE-CELLS; KAPPA-B PATHWAY; TNF-ALPHA; RAT MODEL; ATHEROSCLEROSIS; NIACIN; MICE; EXPRESSION; APOPTOSIS; DEACETYLATION;

D O I：

10.1016/j.intimp.2016.09.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Emerging evidences indicated that NLRP3 inflammasome initiates inflammatory response involved in cardiovascular disease. Nicotinic acid (NA) has been known to possess potential anti-inflammatory property. The aim of this study was to investigate the effect of NA on the activation of NLRP3 inflammasome and the underlying mechanisms. It was found that lipopolysaccharide (LPS) and adenosine triphosphate (ATP) triggered the activation of NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs). NA inhibited NLRP3 inflammasome activation and subsequent caspase-1 cleavage as well as interleukin (IL)-1 beta secretion. Moreover, NA administration up-regulated SIRT1 expression in HUVECs stimulated with LPS plus ATP. Importantly, knockdown of SIRT1 reversed the inhibitory effect of NA on the activation of NLRP3 inflammasome. Further study revealed that NA also decreased the generation of reactive oxygen species (ROS) in HUVECs. In addition, NA inhibited NLRP3 inflammasome activation partly through suppression of ROS. Taken together, these findings indicate that NA is able to regulate the activation of NLRP3 inflammasome in HUVECs, which may be partly mediated by SIRT1 and ROS. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：211 / 218

页数：8

共 43 条

[1] Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector? [J].

Abais, Justine M. ;

Xia, Min ;

Zhang, Yang ;

Boini, Krishna M. ;

Li, Pin-Lan .

ANTIOXIDANTS & REDOX SIGNALING, 2015, 22 (13) :1111-1129

[2] NLRP3 inflammasome in peripheral blood monocytes of acute coronary syndrome patients and its relationship with statins [J].

Altaf, Afrasyab ;

Qu, Peng ;

Zhao, Yang ;

Wang, Hongyan ;

Lou, Dayuan ;

Niu, Nan .

CORONARY ARTERY DISEASE, 2015, 26 (05) :409-421

[3] DENDRITIC CELLS Actin a dangerous part [J].

Bordon, Yvonne .

NATURE REVIEWS IMMUNOLOGY, 2012, 12 (05) :321-321

[4] Endothelial dysfunction: the role of sterol regulatory element-binding protein-induced NOD-like receptor family pyrin domain-containing protein 3 inflammasome in atherosclerosis [J].

Chen, Zhen ;

Martin, Marcy ;

Li, Zhao ;

Shyy, John Y-J. .

CURRENT OPINION IN LIPIDOLOGY, 2014, 25 (05) :339-349

[5] Resveratrol alleviates vascular inflammatory injury by inhibiting inflammasome activation in rats with hypercholesterolemia and vitamin D2 treatment [J].

Deng, Zu Yue ;

Hu, Meng Mei ;

Xin, Yan Fei ;

Gang, Chen .

INFLAMMATION RESEARCH, 2015, 64 (05) :321-332

[6] The protective effects of curculigoside A on adjuvant-induced arthritis by inhibiting NF-κB/NLRP3 activation in rats [J].

Ding, Huimin ;

Gao, Gongming ;

Zhang, Li ;

Shen, Guowei ;

Sun, Wenjian ;

Gu, Zhangping ;

Fan, Weimin .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2016, 30 :43-49

[7] Recent progress in the biology and physiology of sirtuins [J].

Finkel, Toren ;

Deng, Chu-Xia ;

Mostoslavsky, Raul .

NATURE, 2009, 460 (7255) :587-591

[8] Resveratrol Inhibits Ionising Irradiation-Induced Inflammation in MSCs by Activating SIRT1 and Limiting NLRP-3 Inflammasome Activation [J].

Fu, Yue ;

Wang, Yan ;

Du, Liqing ;

Xu, Chang ;

Cao, Jia ;

Fan, Tiqiang ;

Liu, Jianxiang ;

Su, Xu ;

Fan, Saijun ;

Liu, Qiang ;

Fan, Feiyue .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14 (07) :14105-14118

[9] Niacin inhibits fat accumulation, oxidative stress, and inflammatory cytokine IL-8 in cultured hepatocytes: Impact on non-alcoholic fatty liver disease [J].

Ganji, Shobha H. ;

Kashyap, Moti L. ;

Kamanna, Vaijinath S. .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2015, 64 (09) :982-990

[10] Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice [J].

Gao, Peng ;

Xu, Ting-Ting ;

Lu, Jie ;

Li, Li ;

Xu, Jing ;

Hao, De-Long ;

Chen, Hou-Zao ;

Liu, De-Pei .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2014, 92 (04) :347-357

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