The genomic landscape of retinoblastoma: a review

被引：140
作者：
Theriault, Brigitte L. [1 ]
Dimaras, Helen [2 ,5 ,6 ]
Gallie, Brenda L. [1 ,2 ,3 ,4 ,5 ]
Corson, Timothy W. [7 ,8 ,9 ]
机构：
[1] Univ Toronto, Ontario Canc Inst, Princess Margaret Canc Ctr, Campbell Family Canc Res Inst, Toronto, ON M5S 1A1, Canada
[2] Univ Toronto, Dept Ophthalmol & Vis Sci, Toronto, ON M5S 1A1, Canada
[3] Univ Toronto, Dept Med Biophys, Toronto, ON M5S 1A1, Canada
[4] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A1, Canada
[5] Toronto Western Res Inst, Div Visual Sci, Toronto, ON, Canada
[6] Sick Kids Res Inst, Toronto, ON, Canada
[7] Indiana Univ Sch Med, Eugene & Marilyn Glick Eye Inst, Dept Ophthalmol, Indianapolis, IN 46202 USA
[8] Indiana Univ Sch Med, Eugene & Marilyn Glick Eye Inst, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA
[9] Indiana Univ Sch Med, Simon Canc Ctr, Indianapolis, IN 46202 USA
来源：
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | 2014年 / 42卷 / 01期
关键词：
cytogenetics; epigenetics; microRNA; retinoblastoma; single nucleotide polymorphism; MESSENGER-RNA EXPRESSION; HOMOGENEOUSLY STAINING REGIONS; ABERRANT PROMOTER METHYLATION; CHILDRENS ONCOLOGY GROUP; TUMOR-SUPPRESSOR GENE; CELL-LINES; BREAST-CANCER; LUNG-CANCER; HUMAN NEUROBLASTOMA; MICROARRAY ANALYSIS;
D O I：
10.1111/ceo.12132
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Retinoblastoma is a paediatric ocular tumour that continues to reveal much about the genetic basis of cancer development. Study of genomic aberrations in retinoblastoma tumours has exposed important mechanisms of cancer development and identified oncogenes and tumour suppressors that offer potential points of therapeutic intervention. The recent development of next-generation genomic technologies has allowed further refinement of the genomic landscape of retinoblastoma at high resolution. In a relatively short period of time, a wealth of genetic and epigenetic data has emerged on a small number of tumour samples. These data highlight the inherent molecular complexity of this cancer despite the fact that most retinoblastomas are initiated by the inactivation of a single tumour suppressor gene. This review outlines the current understanding of the genomic, genetic and epigenetic changes in retinoblastoma, highlighting recent genome-wide analyses that have identified exciting candidate genes worthy of further validation as potential prognostic and therapeutic targets.
引用
收藏
页码：33 / 52
页数：20
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