Tyrosinase enzyme: 2. Inhibitors from natural and synthetic origins

被引：0

作者：

Casanola-Martin, Gerardo M. ^{[1
,2
]}

Marrero-Ponce, Yovani ^{[2
,3
]}

Huong Le-Thi-Thu ^{[2
]}

Khan, Mahmud Tareq Hassan

Torrens, Francisco ^{[3
]}

Rescigno, Antonio ^{[4
]}

Abad, Concepcion ^{[5
]}

机构：

[1] Ctr Informac & Gest Tecnol Minist Ciencia Tecnol, Ciego De Avila 65100, Cuba

[2] Cent Univ Las Villas, Fac Chem Pharm, Unit Comp Aided Mol Biosil Discovery & Bioinfo, Villa Clara 54830, Cuba

[3] Univ Valencia, Inst Univ Ciencia Mol, E-46071 Valencia, Spain

[4] Univ Cagliari, Dip Sci & Tecnol Biomed, Sez Chim Biol, I-09042 Monserrato, CA, Italy

[5] Univ Valencia, Dept Bioquim & Biol Mol, E-46100 Burjassot, Spain

来源：

AFINIDAD | 2013年 / 70卷 / 564期

关键词：

Tyrosinase inhibitors; Synthetic compounds; Natural products; Drugs; SLOW-BINDING INHIBITOR; MUSHROOM TYROSINASE; CONFORMATIONAL-ANALYSIS; MELANIN BIOSYNTHESIS; POLYPHENOL OXIDASE; MOLECULAR DESIGN; ACTIVE-SITE; KOJIC ACID; IN-VITRO; DERIVATIVES;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this work there are tackled in a general way the tyrosinase inhibitor compounds, the limiting enzyme and the fundamental key for the skin pigmentation control in human beings. The main characteristics of the depigmenting agents used in the medical practice are depicted. Besides, the compounds studied until nowadays are showed, which are grouped taking into account its origin: naturals, synthetics and drug with other therapeutic uses, discovered with inhibitory activity against the enzyme. Finally the last advances in the cheminformatic and molecular modeling field related with the study of the enzyme and its inhibitors are discussed.

引用

页码：270 / 276

页数：7

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