Helper Dependent Adenovirus Vectors: Progress and Future Prospects

被引：29
作者：
Cots, Dan [1 ]
Bosch, Assumpcio [1 ]
Chillon, Miguel [1 ,2 ]
机构：
[1] Univ Autonoma Barcelona, Dept Biochem & Mol Biol, Ctr Anim Biotechnol & Gene Therapy CBATEG, Bellaterra 08193, Spain
[2] ICREA, Barcelona 08010, Spain
来源：
CURRENT GENE THERAPY | 2013年 / 13卷 / 05期
关键词：
Adenovirus; gene therapy; helper vector; helper-dependent vector; immune response; MEDIATED GENE-TRANSFER; INNATE IMMUNE-RESPONSE; FULL-LENGTH DYSTROPHIN; SUSTAINED PHENOTYPIC CORRECTION; CRIGLER-NAJJAR-SYNDROME; LONG-TERM CORRECTION; I CLINICAL-TRIAL; DISEASE TYPE IA; HIGH-CAPACITY; TRANSGENE EXPRESSION;
D O I：
10.2174/156652321305131212125338
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Sixteen years after Graham and coworkers described the most used system for generating helper-dependent adenovirus (HDAd) vectors, production systems have evolved considerably, and most resulting preparations have titres of 1 x 10(13) IU/ml (infection units/ml) and very low helper contamination levels (<0.1%). These advances in production, as well as the attractive characteristics of these vectors (large insert capacity and low cell immune response compared with first-generation Ad vectors) make them very interesting for many research purposes as they have become more accessible to the scientific community. In this review we summarise the latest strategies for producing HDAd vectors, describe the main areas of interest for which HDAd vectors are being used, and comment on the future prospects for HDAd vectors in gene therapy.
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收藏
页码：370 / 381
页数：12
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