Three new secoiridoids, swermacrolactones A-C and anti-hepatitis B virus activity from Swertia macrosperma

被引：26
|
作者：
Wang, Hong-Ling [1 ,2 ]
Geng, Chang-An [1 ]
Ma, Yun-Bao [1 ]
Zhang, Xue-Mei [1 ]
Chen, Ji-Jun [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100039, Peoples R China
来源：
FITOTERAPIA | 2013年 / 89卷
基金：
中国国家自然科学基金; 中国科学院西部之光基金;
关键词：
Secoiridoids; Swermacrolactones A-C; Anti-HBV activity; Swertia macrosperma; Gentianaceae; JAPONICA MAKINO; ANGUSTIFOLIA; MILEENSIS;
D O I：
10.1016/j.fitote.2013.06.002
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three new secoiridoids, swermacrolactones A-C (1-3), together with fourteen known compounds were isolated from Swertia macrosperma. Their structures were elucidated based on extensive spectroscopic analyses (IR, UV, MS, 1D and 2D NMR). By anti-HBV assay on the Hep G 2.2.15 cell line in vitro, the most active compound, luteolin (9), inhibited the secretion of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg) with IC50 values of 0.02 and 0.02 mM, respectively. (c) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：183 / 187
页数：5
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