Evaluation of a Self-Administered Oral Glucose Tolerance Test

被引:15
作者
Bethel, M. Angelyn [1 ,2 ]
Price, Hermione C. [1 ,2 ]
Sourij, Harald [1 ]
White, Sarah [1 ]
Coleman, Ruth L. [1 ]
Ring, Arne [1 ,2 ]
Kennedy, Irene E. C. [1 ,2 ]
Tucker, Lynne [1 ,2 ]
Holman, Rury R. [1 ,2 ]
机构
[1] Univ Oxford, Diabet Trials Unit, Translat Res Grp, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England
[2] NIHR Oxford Biomed Res Ctr, Oxford, England
关键词
COST; ASSOCIATION; AGREEMENT;
D O I
10.2337/dc12-0643
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE-To assess the feasibility of using a disposable, self-administered, capillary blood sampling oral glucose tolerance test (OGTT) device in a community setting. RESEARCH DESIGN AND METHODS-Eighteen healthy and 12 type 2 diabetic volunteers underwent six 75-g OGTTs using a prototype device in the following three settings: unaided at home (twice); unaided but observed in clinic (twice); and performed by a nurse with simultaneous laboratory glucose assays of 0- and 120-min venous plasma samples (twice). The device displayed no results. A detachable data recorder returned to the clinic provided plasma-equivalent 0- and 120-min glucose values and key parameters, including test date, start and end times, and time taken to consume the glucose drink. RESULTS-The device was universally popular with participants and was perceived as easy to use, and the ability to test at home was well liked. Device failures meant that 0- and 120-min glucose values were obtained for only 141 (78%) of the 180 OGTTs performed, independent of setting. Device glucose measurements showed a mean bias compared with laboratory-measured values of +0.9 at 5.0 mmol/L increasing to +4.4 at 15.0 mmol/L. Paired device glucose values were equally reproducible across settings, with repeat testing showing no training effect regardless of setting order. CONCLUSIONS-Self-administered OGTTs can be performed successfully by untrained individuals in a community setting. With improved device reliability and appropriate calibration, this novel technology could be used in routine practice to screen people who might need a formal OGTT to confirm the presence of impaired glucose tolerance or diabetes.
引用
收藏
页码:1483 / 1488
页数:6
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