Antifungal mechanism of FK463 against Candida albicans and Aspergillus fumigatus

被引：62
作者：
Hatano, K [1 ]
Morishita, Y [1 ]
Nakai, T [1 ]
Ikeda, F [1 ]
机构：
[1] Fujisawa Pharmaceut Co Ltd, Med Biol Res Labs, Yodogawa Ku, Osaka 5328514, Japan
来源：
JOURNAL OF ANTIBIOTICS | 2002年 / 55卷 / 02期
关键词：
D O I：
10.7164/antibiotics.55.219
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
[No abstract available]
引用
收藏
页码：219 / 222
页数：4
相关论文
共 13 条
[1]   CHARACTERIZATION AND CILOFUNGIN INHIBITION OF SOLUBILIZED ASPERGILLUS-FUMIGATUS (1,3)-BETA-D-GLUCAN SYNTHASE [J].
BEAULIEU, D ;
TANG, J ;
YAN, SB ;
VESSELS, JM ;
RADDING, JA ;
PARR, TR .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (05) :937-944
[2]   Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors [J].
Douglas, CM ;
DIppolito, JA ;
Shei, GJ ;
Meinz, M ;
Onishi, J ;
Marrinan, JA ;
Li, W ;
Abruzzo, GK ;
Flattery, A ;
Bartizal, K ;
Mitchell, A ;
Kurtz, MB .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (11) :2471-2479
[3]   THE SACCHAROMYCES-CEREVISIAE FKS1 (ETG1) GENE ENCODES AN INTEGRAL MEMBRANE-PROTEIN WHICH IS A SUBUNIT OF 1,3-BETA-D-GLUCAN SYNTHASE [J].
DOUGLAS, CM ;
FOOR, F ;
MARRINAN, JA ;
MORIN, N ;
NIELSEN, JB ;
DAHL, AM ;
MAZUR, P ;
BAGINSKY, W ;
LI, WL ;
ELSHERBEINI, M ;
CLEMAS, JA ;
MANDALA, SM ;
FROMMER, BR ;
KURTZ, MB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (26) :12907-12911
[4]   Efficacy of FK463, a new lipopeptide antifungal agent, in mouse models of disseminated candidiasis and aspergillosis [J].
Ikeda, F ;
Wakai, Y ;
Matsumoto, S ;
Maki, K ;
Watabe, E ;
Tawara, S ;
Goto, T ;
Watanabe, Y ;
Matsumoto, F ;
Kuwahara, S .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (03) :614-618
[5]   Cloning of the RHO1 gene from Candida albicans and its regulation of beta-1,3-glucan synthesis [J].
Kondoh, O ;
Tachibana, Y ;
Ohya, Y ;
Arisawa, M ;
Watanabe, T .
JOURNAL OF BACTERIOLOGY, 1997, 179 (24) :7734-7741
[6]   MORPHOLOGICAL EFFECTS OF LIPOPEPTIDES AGAINST ASPERGILLUS-FUMIGATUS CORRELATE WITH ACTIVITIES AGAINST (1,3)-BETA-D-GLUCAN SYNTHASE [J].
KURTZ, MB ;
HEATH, IB ;
MARRINAN, J ;
DREIKORN, S ;
ONISHI, J ;
DOUGLAS, C .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (07) :1480-1489
[7]   Efficacy of FK463, a new lipopeptide antifungal agent, in mouse models of pulmonary aspergillosis [J].
Matsumoto, S ;
Wakai, Y ;
Nakai, T ;
Hatano, K ;
Ushitani, T ;
Ikeda, F ;
Tawara, S ;
Goto, T ;
Matsumoto, F ;
Kuwahara, H .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (03) :619-621
[8]   In vitro activity of 1,3-beta-D-glucan synthase requires the GTP-binding protein Rho1 [J].
Mazur, P ;
Baginsky, W .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (24) :14604-14609
[9]   Cloning of the Candida albicans homolog of Saccharomyces cerevisiae GSC1/FKS1 and its involvement in beta-1,3-glucan synthesis [J].
Mio, T ;
AdachiShimizu, M ;
Tachibana, Y ;
Tabuchi, H ;
Inoue, SB ;
Yabe, T ;
YamadaOkabe, T ;
Arisawa, M ;
Watanabe, T ;
YamadaOkabe, H .
JOURNAL OF BACTERIOLOGY, 1997, 179 (13) :4096-4105
[10]   CILOFUNGIN (LY121019) INHIBITS CANDIDA-ALBICANS (1-3)-BETA-D-GLUCAN SYNTHASE ACTIVITY [J].
TAFT, CS ;
STARK, T ;
SELITRENNIKOFF, CP .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (12) :1901-1903
12