Etiology of aortic dissection

被引：57

作者：

Akutsu, Koichi ^{[1
]}

机构：

[1] Kawasaki Saiwai Hosp, Kawasaki Aort Ctr, Dept Cardiovasc Surg, Div Vasc Med,Saiwai Ku, 31-21 Ohmiya Cho, Kawasaki, Kanagawa 2120014, Japan

来源：

GENERAL THORACIC AND CARDIOVASCULAR SURGERY | 2019年 / 67卷 / 03期

关键词：

Aortic dissection; Etiology; Medial degeneration; Shear wall stress; Connective tissue disorder; Vasa vasorum; INTERNATIONAL REGISTRY; THORACIC AORTA; SLEEP-APNEA; SURGICAL PATHOLOGY; VASA VASORUM; ROOT MOTION; MUTATIONS; ANEURYSM; VALVE; RISK;

D O I：

10.1007/s11748-019-01066-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We discuss the etiology of aortic dissection (AD) from various points of view. The development of AD requires two pathological conditions: medial degeneration and mechanical wall stress. First, histopathological findings of medial degeneration are hypothesized to be due to a loss of elastic fibersandinterconnecting elastic fibers. Damage to the vasa vasorum plays a key role in creating an entry site. The clinical causes of medial degeneration include hypertension, aortic aneurysms, obstructive sleep apnea, and connective tissue disorders. Second, mechanical wall stress is supposedly induced by shear stress caused by blood flow, together with hypertension and aortic root movement. Further investigation is necessary in the search for mechanisms responsible for medial degeneration prior to AD development.

引用

收藏

页码：271 / 276

页数：6

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